22

Question 1

Internal validity

Answer 1

How representitive is or study population / estimate is of our true population MOA

Question 2

Three key things that impact internal validity

Answer 2

Chance
Bias
Confounding

Question 3

External validation

Answer 3

Extent to which study findings are representitve to a broader or different population

• generalisability

Question 4

Chance is

Answer 4

Random error

Question 5

What does increasing sample size do?

Answer 5

Decrease sample variability - standard deviation
Increases precision of parameter estimate
Increases likely hood of getting a representitive study

(Can’t estimate sample error but can reduce it by increasing sample size)

Question 6

How do we measure INFLUENCE of sampling error

Answer 6

• confidence intervals
• p values

Question 7

Small CI is good

Answer 7

Yes

Question 8

The bigger the study, the narrower the CI tends to be therefore more precise the parameter estimate is

Answer 8

Yes

Question 9

Clinical importance

Answer 9

RCT state that they consider to be clinically important
Confidence intervals help determine whether something is clinically significant