2013 Perrino Cancer Flashcards
cancers of epithelium are called?
carcinomas
Cancers of connectve tissues or muscles cells are called?
sarcomas
What is kaposi’s sarcoma connected to?
AIDS
what are cells that arise form hemopoietic cells and cancers derived from cells of the nervous system?
leukemias, lymphomas
what is the most common cancer?
reproductive cancer
What are the two cancers that have a near 100% death rate/new occurance rate?
nervous system, connective tissue, muscles and vasculature
most cancers are classified as what?
eptihelial cancers so carcinomas
Cancer cells often maintain characteristics of their (blank) ,and cancers originating from different cell types are usually very different diseases.
tissue of origin
What is a tumor growing at the anatomical site where the tumor originated and tumor progression began and proceeded to yield a cancerous mass called?
primary tumor
Most cancers arise from a (blank)
single abnormal cell
What showed evidence that cancer arises from single abnormal cell?
- all cells of a particular cancer have same chromosome breakage point (phili 9-33 CML)
- all cells of particular cancer have same x-inactivation
carcinogenesis is linked with (blank)
mutagenesis
Correlation between carcinogens and mutations
(blank) generally cause point mutations in a DNA sequence
chemical carcinogens
Correlation between carcinogens and mutations
(blank) generally cause chromosome breaks and translocations
ionizing radiation x-rays
Correlation between carcinogens and mutations
(Blank) introduce foreign DNA into cells
transforming viruses
Tumor progression: the development of cancer requires the accumulation of mutations In many (blank)
genes
What are the stages in development of cervical carcinoma?
normal->low-grade epithelial neoplasia-> invasive carcinoma
Incidence of bladder cancers in workers exposed to 2-napthylamine showed what?
- Cancers arise years after exposure to chemical carcinogens
- It takes Years of exposure are required for cancers to develop
the tumor (blank) plays an important role in tumor survival and growth.
microenvironment
What is the key property of all cancer cells?
1) They disregard the external and internal signals that regulate cell proliferation
2) avoid suicide by apoptosis
3) They circumvent programmed limitations to proliferation escaping replicative senescence and/or avoiding differentiation
4) genetically unstable (p53)
5) they escape from tissue of origin (invasive)
6) they survive and proliferate in foreign sites (they metastasize)
7) cancer stem cells maintain many tumors
a class of about 100 genes that have been identified that are repeatedly altered in different cancers are called the cancer (blank).
critical genes