2009 lessons mcq

Question 1

acute phase response involves

Answer 1

involves the liver, raised CRP and IL-1

Question 2

NK cells

Answer 2

are of the myeloid lineage

have an FcgammaR

Question 3

in granulation tissue

Answer 3

metalloproteinases are required for tissue remodelling

there is increased MHC expression

Question 4

the Fc portion can

Answer 4

• is required for IgA mucosal trasfer
• imp in triggering IgE mediated hypersensitivity
• of IgG can activate C1q

Question 5

lymphocyte activation

Answer 5

CD28 is present on T cells

cross linking CD40 on B cells promotes their proliferation

Question 6

cytokines

Answer 6

IL-12 is proinflammatory
IL4 drives Th2 responses
IL8 is chemotactic for neutrophils
IFNgamma is proinflammatory

Question 7

Th1 is -

Th2 is -

Answer 7

Th1 is cell mediated

Th2 is humoural mediated

Question 8

Th1 responses are

Answer 8

important in controlling mycobacterial infections

and are promoted by high TCR affinity

Question 9

CD4 and CD25+ cells?

Answer 9

supressor cells that may control autoreactive T cells

Question 10

autoimmunity

Answer 10

immune complex deposition my cause vasculitis

most autoimmune disease show a genetic ASSOCIATION with MHC

Question 11

transplantation, indirect recognition?

Answer 11

is due to uptake of allogenic proteins by the recipient’s own antigen presenting cells

Question 12

HSV encodes

Answer 12

a ribonucleotide reductase
is dsDNA
replicates in the nucleus

Question 13

HIV can be acquired congenitally

Answer 13

-

Question 14

poliovirus is

Answer 14

a picornavirus
ssRNA
posseses an IRES
has an icoahedral capsid
transmitted faeco-orally

Question 15

acyclovir (zovirax)

Answer 15

inhibits HSV DNA replication and is an analogue of thymidine

Question 16

influenza HA permits

Answer 16

infection of erythrocytes

Question 17

transmissible spongifor encephalopathies are

Answer 17

caused by abnormally folded PrP molecules
can be transmitted orally
can be inherited
degenerate the CNS
cannot be vaccinated against

Question 18

plasmodium falciparum

Answer 18

glycosyl phosphatidyl inositol (GPI) is proinflammatory
sporozoites invade liver cells
sequestration of infected RBCs is via var gene products
thalassaemias can confer protection

Question 19

parasites

Answer 19

onchocerca volvulus is the black fly bite transmited parasite causing river blindness
in humans, helminths generally elicit a Th2 response
wucheria bancrofti produces microfilaria and is one of three parasites that can cause filariasis and is transmitted by mosquitos