2009 lessons mcq Flashcards
acute phase response involves
involves the liver, raised CRP and IL-1
NK cells
are of the myeloid lineage
have an FcgammaR
in granulation tissue
metalloproteinases are required for tissue remodelling
there is increased MHC expression
the Fc portion can
- is required for IgA mucosal trasfer
- imp in triggering IgE mediated hypersensitivity
- of IgG can activate C1q
lymphocyte activation
CD28 is present on T cells
cross linking CD40 on B cells promotes their proliferation
cytokines
IL-12 is proinflammatory
IL4 drives Th2 responses
IL8 is chemotactic for neutrophils
IFNgamma is proinflammatory
Th1 is -
Th2 is -
Th1 is cell mediated
Th2 is humoural mediated
Th1 responses are
important in controlling mycobacterial infections
and are promoted by high TCR affinity
CD4 and CD25+ cells?
supressor cells that may control autoreactive T cells
autoimmunity
immune complex deposition my cause vasculitis
most autoimmune disease show a genetic ASSOCIATION with MHC
transplantation, indirect recognition?
is due to uptake of allogenic proteins by the recipient’s own antigen presenting cells
HSV encodes
a ribonucleotide reductase
is dsDNA
replicates in the nucleus
HIV can be acquired congenitally
-
poliovirus is
a picornavirus ssRNA posseses an IRES has an icoahedral capsid transmitted faeco-orally
acyclovir (zovirax)
inhibits HSV DNA replication and is an analogue of thymidine
influenza HA permits
infection of erythrocytes
transmissible spongifor encephalopathies are
caused by abnormally folded PrP molecules can be transmitted orally can be inherited degenerate the CNS cannot be vaccinated against
plasmodium falciparum
glycosyl phosphatidyl inositol (GPI) is proinflammatory
sporozoites invade liver cells
sequestration of infected RBCs is via var gene products
thalassaemias can confer protection
parasites
onchocerca volvulus is the black fly bite transmited parasite causing river blindness
in humans, helminths generally elicit a Th2 response
wucheria bancrofti produces microfilaria and is one of three parasites that can cause filariasis and is transmitted by mosquitos
