2008 mcq Flashcards

1
Q

regarding tolerance

A

most proteins are naturally highly immunogenic
cross linking of surface Ig may cause apoptosis of B-lymphocytes in the bone marrow
central tolerance occurs in the bone marrow and thymus

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2
Q

define allograft

A

a graft from a non identical individual

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3
Q

foreign antigen presented by B lymphocytes is taken up usually by?

A

by the B cell receptor not phagocytosis

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4
Q

human graft rejection

A

not due to beta microglobulin subtypes

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5
Q

IL10 ?

A

antiinflammatory cytokine

promotes Th2 response

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6
Q

some factors involved in acute inflammation

A

COX2, iNOS, platelet activating factor

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7
Q

B lymphocytes

A

do no individually express both kappa and lamba light chains

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8
Q

delayed type hypersensitivity type 4 response

A

mediated by T cells

is significantly associated with mycobacterial infections

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9
Q

antibody diversity is generated by

A

different heavy and light chain combinations
somatic hypermutation
junctional diversity

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10
Q

immune response to novel virus

A

IFNalpha is important reactant
TNFalpha is relevant
IL12 is relevant

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11
Q

some viruses that synthesise progeny genomes in the nucleus

A

herpes
lentivirus
papillomaviruses

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12
Q

influenza virus

A

typically induces upper respiratory tract infections

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13
Q

some DNA viruses

A

HBV, adenoviruses, poxviruses, reoviruses

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14
Q

some pathogenic effects of virus infection can be caused by interferon

A

-

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15
Q

trypanosoma brucei gambeniense

A

causes sleeping sickness

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