2008 mcq Flashcards
regarding tolerance
most proteins are naturally highly immunogenic
cross linking of surface Ig may cause apoptosis of B-lymphocytes in the bone marrow
central tolerance occurs in the bone marrow and thymus
define allograft
a graft from a non identical individual
foreign antigen presented by B lymphocytes is taken up usually by?
by the B cell receptor not phagocytosis
human graft rejection
not due to beta microglobulin subtypes
IL10 ?
antiinflammatory cytokine
promotes Th2 response
some factors involved in acute inflammation
COX2, iNOS, platelet activating factor
B lymphocytes
do no individually express both kappa and lamba light chains
delayed type hypersensitivity type 4 response
mediated by T cells
is significantly associated with mycobacterial infections
antibody diversity is generated by
different heavy and light chain combinations
somatic hypermutation
junctional diversity
immune response to novel virus
IFNalpha is important reactant
TNFalpha is relevant
IL12 is relevant
some viruses that synthesise progeny genomes in the nucleus
herpes
lentivirus
papillomaviruses
influenza virus
typically induces upper respiratory tract infections
some DNA viruses
HBV, adenoviruses, poxviruses, reoviruses
some pathogenic effects of virus infection can be caused by interferon
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trypanosoma brucei gambeniense
causes sleeping sickness