2 - MZH - Meiosis Flashcards
Define meiosis
Form of cell division where the nucleus divides twice (meiosis 1 and meiosis 2) resulting in a halving of the chromosome number and producing 4 haploid cells from one diploid cell.
State the 5 ways by which meiosis can create genetic variation?
- Crossing over in prophase 1
- Independant assortment in metaphase 1 (bivalents arrange themselves randomly)
- Independant assortment in metaphase 2
- Mutations
- Random fusion of gametes during fertilisation
What happens in meiosis 1
First division - Reduction division
Pairs of homologous chromosomes are seperated in to 2 cells.
Each intermediate cell will only contain one full set of genes instead of two, so the cells are haploid.
What happens in meiosis 2
Similar process to meiosis 1.
Pairs of daughter chromatids seperate into 2 cells. 4 haploid cells are produced.
Purpose of the cells produced by meiosis being haploid?
Ensures that the chromosome number remains constant from one generation to the next.
Interphase?
DNA of each chromosome replicated forming 2 identical chromatids hed together at the centromere.
Each cell now contins 4, rather than the original 2 copies of each chromosome.
Prophase 1?
- Chromosomes cndense (shorten + fatten).
- Come together in their homologous pairs to form a bivalent (group of 4 chromatids).
- Chromatids wrap one another and attach at points called chiasmata.
- Crossing over takes place - produces genetic variation
Metaphase 1?
- Independant assortment occurs (produces genetic variation)
- Centomeres attach themselves to the spndle fibires and the bivalents arrange themselves randomly at the equator (metaphase plate).
Anaphase 1?
DIFFERENT TO ANAPHASE OF MITOSIS!
- One of each pair of homologous chromosomes is pulled by spindle fibres to opposite poles.
- Depending on how the chromosomes lined up on the equator different combinations of chromosomes will end up at the poles. (independant assortment)
- Sister chromatids are no longer identical.
Telophase 1?
- Chromosomes assemble at each pole, nuclear membrane reforms, chromosomes uncoil.
- Cell undergoes cytokinesis and divides into 2 cells.
- Reduction of chromosome number from diploid to haploid is complete.
Cytoplasm divides and 2 cells are formed. These cells them immediately enter meiosis 2!
There is no interphase between meiosis 1 and meiosis 2.
Which stage does not exist between meiosis 1 and meiosis 2?
Interphase
Prophase 2?
No chiasmata is formed so no chrossing over occurs.
- Nuclear envelope breaks down, chromosomes condense and become visible.
- Spindle formation begins.
Metaphase 2?
Independant assortment occurs - individual chromosomes assemble on the metaphase plate (randomly).
Anaphase 2?
Chentromeres divide, daughter chromatids are pulled to opposite poles by the spindle fibres.
Telophase 2?
- Nuclear envelope reforms again.
- Chromosomes uncoil and form chromatin again.
- Cytokinesis occurs and forms 4 daughter cells in total.
- Cells will be haploid due to the reduction division (meiosis 1).
- All 4 cells have a different genetic composition.