2. Membranes and Membrane Transport Flashcards

1
Q

What is the most common Sphingolipid in the outer leaflet of the PM?

A

Sphingomyelin

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2
Q

What is the location and function of Phosphatidylserine in the plasma membrane?

A

Phosphatidylserine is found in the inner leaflet in healthy cells, but during apoptosis, phosphatidylserine swaps to the outer leaflet.

This is because phosphatidylserine is used as a label for phagocytosis for dying cells.

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3
Q

Name the following for Niemann-Pick disease.

  • Enzyme that is deficient
  • Function of that enzyme
  • Location of effect
  • Symptoms
  • Hallmark sign
  • Fatality rate for type A
A
  • Acid Sphingomyelinase (A-SMase)
  • Lysosomal enzyme that breaks down Sphingomyelin
  • Lysosomes of Liver, Spleen, CNS and Bone marrow
  • Enlargement of Liver and Spleen, Neurological Damage
  • Cherry red spot in the eye
  • 85% by 18 months of age
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4
Q

The disease in which a mother’s anti Rh+ antibodies attack the fetus is known as…

A

Erythroblastosis Fetalis

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5
Q

Detail the following for Spur Cell Anemia

  • What cell is affected?
  • What is wrong with these cells?
  • What causes the actual anemia?
A
  • Red Blood Cells
  • They have decreased membrane fluidity due to elevated cholesterol
  • Red blood cells lyse as they are squished through the capillaries of the spleen.
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6
Q

What sort of molecules can use Simple Diffusion?

A

Small molecules that are non-polar, or uncharged polar.

Small Nonpolar Examples

O2, N2, Ethanol, Diethylether, Benzene

Small polar uncharged Examples

Water, CO2, Urea, NH3

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7
Q

What is Mimantine / Namenda?

A

Glutamate receptor antagonist, which prevents opening of an ion channel. Treats Alzheimer’s disease.

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8
Q

What residue is phosphorylated in P type ATPases?

A

Aspartate residue

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9
Q

What is unique about the use of ATP in ABC Transporters?

A

ATP is hydrolyzed, but does not phosphorylate the protien.

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10
Q
  • What does SGLT 1 move? (2)
  • Where does it move it?
  • Where does it get the energy?
A
  • D-Glucose and D-Galactose
  • From the intestinal lumen into the intestinal epithelial cells
  • Using the high amount of sodium outside the cell, and bringing it along to the inside.
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11
Q
  • What transporter brings Fructose into the intestinal epithelial cells?
  • What type of diffusion does this transporter use?
A
  • GLUT 5
  • Facillitated Diffusion (not active transport)
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12
Q

What transporter moves D-Glucose, D-Galactose, and Fructose, out of the intestinal epithelial cells, and into the blood?

A

GLUT 2

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13
Q

For Cystic Fibrosis

  • What protien is misfolded?
  • What does that protein do?
  • What does this defective protien cause?
  • What are the symptoms?
A
  • Cystic Fibrosis Transmembrane Conductance Regulator
  • Active Transport of Chloride from inside cells to the outside in airways and sweat ducts (using ATP)
  • Buildup of Cl- inside the airway epithelial cells, which attracts Na+, which in turn causes water to stay in the cells, and not go to the surface mucous layer.
  • Increased incidence of respiratory bacterial infections
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14
Q

For Cystinuria

  • What is the etymology of the disease?
  • What fails to transport?
  • What does this cause?
  • What is the presentation?
A
  • Genetic: Autosomal Recessive
  • Dibasic amino acids. Cystine, Arginine, Lysine, Ornithine
  • Cystine crystals in the kidney
  • Renal Cholic, abdominal pain that comes in waves and is linked to kidney stones
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15
Q

For Hartnup disease

  • What is the etymology?
  • What is defective?
  • What ends up being deficient as a result?
  • What are the clinical findings?
A
  • Genetic: Autosomal recessive
  • Transporter for Non-Polar and Neutral amino acids, like Alanine, Valine, Threonine, Leucine, and Tryptophan.
  • Serotonin, Melatonin, Niacin, and NAD+. All are synthesized from Tryptophan.
  • Cerebellar ataxia (lack of coordination), Photodermatitis, Photosensitivity, and Nystagmus.
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16
Q

What are Cardiotonic drugs used for?

A

Atrial Fibrilation and CHF

17
Q

Cardiotonic drugs like ouabain and digoxin fall into what class?

A

Cardiac Glycosides

18
Q

What do cardiotonic drugs do?

A

Inhibit the Na+ / K+ -ATPase on cardiac myocytes. This results in more intracellular Na+ and therefore, a slower Sodium Calcium Exchanger. This means Calcium goes up, and so does contractions.