2 L9 Cells in Tissues 4

Question 1

3 main stages of inflammation

Answer 1

Vascular dilation - Endothelial activation - Neutrophil activation and migration

Question 2

Describe Vasodilation

Answer 2

Chemical mediators act on local blood vessels. Substances released from dead/damaged tissues

Question 3

Endothelial contraction

Answer 3

Allows the tissue to become swollen - Endothelial activation cell swelling and activation - Increased permeability: water, salts and proteins pass into damaged area

Question 4

Leukocyte migration and activation

Answer 4

Damaged area becomes progressively replaced by components of the exudate - Neutrophils adhere to epithelium (margination) - Neutrophils actively migrate into area of damage (migration) - Fibrin is polymerised in tissue from fibroginen

Question 5

3 outcomes of acute inflammation

Answer 5

Regeneration - Organisation and Repair (healing by fibrosis) - Chronic inflammation

Question 6

3 things that affect outcome of acute inflammation

Answer 6

Severity of tissue damage - Capacity of specialised to replicate and regrow (regenerate) - Type of agent to cause the tissue damage

Question 7

2 factors needed for restoration of normal function without scarring

Answer 7

Stroma must be intact (connective tissue framework of tissue) - Damaged cells must be capable of regenerating

Question 8

What determines the extent of healing

Answer 8

The level of tissue deficit

Question 9

Macrophage role in tissue repair and following event

Answer 9

Machrophage enter damaged area and remove debris. Granulation tissue is laid down

Question 10

What do macrophages promote

Answer 10

Fibroblast migration and vascularisation