2 L10 Skeletal Muscle Structure

Question 1

How does skeletal muscle generate force

Answer 1

Via parallel contraction

Question 2

What is the ratio of actin to myosin filaments

Answer 2

2:1 2 actin to 1 myosin

Question 3

3 muscle types

Answer 3

Cardiac - Skeletal - Smooth

Question 4

Describe structure of muscle from smallest to largest

Answer 4

Myofilaments - Sarcomere - Myofibril - Muscle fibre - Fascicle - Muscle

Question 5

Describe structure and location of the nucleus in muscle cells

Answer 5

Myofibres are multinucleated- formed by multiple myoblasts fusing to make a single cell
Nucleus are peripherally nucleated

Question 6

What intermediate filaments are located in between myofibrils

Answer 6

Desmin and vimentin

Question 7

Describe alpha actinin

Answer 7

Primary component of Z-line
Most cytoskeletal proteins can bind to alpha actinin

Question 8

Describe titin

Answer 8

Large structural protein that connects myosin filaments to Z-line. Each thick filament has titin core that recoils after stretching

Question 9

Describe neubulin

Answer 9

Structural protein in thin filament - Can act as length determinant for entire actin filament

Question 10

What does the triad compose of

Answer 10

2 SR cisterna, T-tubule