2: Cells and tissues of the immune system Flashcards
what happens to eosinophils after leaving bone marrow
migrate to the spleen where they mature, then migrate into tissues
what are eosinophils responsible for (3)
- phagocytosis and killing of parasites
- Fc receptors on surface to bind antibodies
- produce cytokines
what do eosinophilic granules contain (3)
- phosphatase
- peroxidase
- toxic proteins
what do basophil granules contain
inflammatory molecules (histamine, serotonin)
what do basophils do
play a role in killing of parasites due to presence of FceRI
what do mast cells do
play a role in killing of parasites due to presence of FceRI
what do mast cell granules contain
vasoactive amines (histamine, serotonin)
what is adaptive immune response mediated by
lymphocytes
what is adaptive immunity specific to
a given molecule (epitope –> 8-12 amino acids)
what does adaptive immune system do (3)
- has surface receptors for antigens on pathogens or particles
- provides specific immunity to antigens
- provides memory of specific antigens
what do b cells do (3)
- produce antibodies
- antibodies bind antigens
- antibodies interact with components of the innate immune system
what do t cells do (3)
- recognize processed antigen on host cells (cell mediated immunity)
- helper t cells activate or regulate activities of other cells
- cytotoxic t cells kill host cells bearing a foreign antigen
what is clonal selection
lymphocytes undergo clonal selection based on an individual cell having the correct receptor for a very small, defined part of a larger antigen
what happens to lymphocyte receptors
genome rearranges randomly at the site where the receptors are encoded –> generates cells of the same type but with different receptors
what do lymphoid organs have sites for
- sites where lymphocytes develop and/or contact and respond to specific antigens
- points of differentiation, antigen and immune cell collection, and adaptive immune responses
places of differentiation and activation
- differentiation: primary organ
- activation: secondary organ