1: Concepts and cells Flashcards

1
Q

2 types of immunity

A
  • innate

- adaptive

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2
Q

2 types of innate immunity

A
  • humoral

- cellular

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3
Q

types of innate humoral immunity (3)

A
  • complement
  • cytokines/chemokines
  • antimicrobial peptides
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4
Q

types of innate cellular immunity (3+)

A
  • monocytes (macrophages, dendritic cells)
  • natural killer cells
  • granulocytes (mast cells, eosinophils, basophils, neutrophils)
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5
Q

adaptive humoral immunity

A

antibodies

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6
Q

types of adaptive cellular immunity (2+)

A
  • b cells

- t cells (helper, cytotoxic, regulatory)

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7
Q

3 components of the immune system

A
  • soluble components
  • cellular components
  • tissues
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8
Q

importance of soluble components of the immune system (3)

A
  • released by immune cells, fibroblasts, etc
  • affect differentiation and activities of immune cells
  • can have direct action on invading pathogens/tumors
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9
Q

importance of cellular components of immune system (2)

A
  • innate responses

- adaptive responses

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10
Q

importance of tissues of the immune system

A
  • primary organs

- secondary organs

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11
Q

where do all cells of the immune system arise from

A

bone marrow precursors

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12
Q

what drives differentiation of immune cells down the pathway

A

cytokines

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13
Q

2 types of progenitor cells

A
  • lymphoid

- myeloid

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14
Q

what do lymphoid progenitors become (3) and where

A
  • b cells, t cells, nk cells

- bone marrow then lymph nodes

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15
Q

what do myeloid progenitors become (3) and where

A
  • granulocytes, platelets, erythrocytes

- bone marrow, blood, tissues

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16
Q

another word for white blood cells

A

leukocytes

17
Q

where do leukocytes originate from

A

in the bone marrow from hematopoetic stem cells

18
Q

another name for neutrophils

A

PMNs (polymorphonuclear neutrophil granulocyte)

19
Q

what are neutrophils responsible for

A

phagocytosis and digestion of bacteria and particles

20
Q

nucleus and staining of neutrophils

A
  • multi-lobed nuclei

- cytoplasmic granules that stain with natural dyes

21
Q

neutrophil life span

A

short (2 days)

22
Q

what is most important phagocytic cell

A

macrophage

23
Q

what is most numerous cellular component of innate immunity

A

neutrophils

24
Q

activities of macrophages (3)

A
  • regulating homeostatic processes
  • wound healing
  • phagocytosis and killing bacteria
25
Q

what do macrophages secrete

A

pro-inflammatory cytokines

26
Q

what do macrophages present

A

processed antigens to t-cells

27
Q

what do macrophages help to do

A

initiate adaptive immune response

28
Q

where are dendritic cells located

A
  • skin, intestinal, respiratory, reproductive tract mucosa

- migrate to draining lymph nodes

29
Q

main importance of dendritic cells

A

most important antigen presenting cell (links innate and adaptive immunity)

30
Q

where do lymphocytes arise from

A

lymphoid progenitor in bone marrow or bursa

31
Q

where do b and t cells mature

A

b in lymph nodes, t in thymus

32
Q

what do lymphocytes mediate

A

adaptive (antigen-specific) immunity

33
Q

where are lymphocytes found

A

blood, lymphoid organs

34
Q

what do lymphocytes undergo once they are “selected”

A

clonal replication

35
Q

steps in lymphocyte replication

A
  • single progenitor cell gives rise to many lymphocytes with different specificities
  • removal of self-reactive ones
  • pool of mature naive lymphocytes left
  • foreign antigen causes proliferation and differentiation of activated specific lymphocytes
36
Q

what is different about natural killer cells

A
  • different antigen receptors than B or T cells

- don’t require thymus for differentiation

37
Q

what do NK cells do (3)

A
  • kill tumor cells and virally-infected cells
  • possess an Fc receptor allowing them to bind to many types of antibodies
  • secrete interferons (cytokine activating other cells to be anti-viral)