2) c) iii) Reversible Binding of Phosphate Flashcards
addition or removal of a phosphate causes?
The addition or removal of phosphate can cause reversible conformational change in proteins
The addition or removal of a phosphate is?
This is a common form of post-translational modification
What enzyme is responsible for transfer of a phosphate to another protein
Protein kinases catalyse the transfer of a
phosphate group to other proteins
The terminal phosphate of ATP is transferred to specific R groups
What protein is responsible for the reverse reaction? What
Protein phosphatases catalyse the reverse reaction
What does phosphorylation do?
Phosphorylation brings about conformational changes, which can affect a protein’s activity
The activity of many cellular proteins, such as enzymes and receptors, is regulated in this way
Some proteins are activated by
phosphorylation while others are inhibited
addition of a phosphate adds what charge?
Adding a phosphate group adds negative
charges. Ionic interactions in the
unphosphorylated protein can be disrupted and new ones created.