2/24 UWORLD test # 23 Flashcards
Q 1. Describe what feature of HIV viral replication results in antigenic variation in each cycle. How host immune response against virus is affected?
-
Q 1. What is fate of viral envelope protein after each replication cycle. Does it has immunogenecity?
-
Q 2. Neural tube defect: what abnormality during embryonic development results in anencephaly? what about spina bifida?
-
-
Q 2. failure of neural tube formation (by closure of neural pore) results in release of what two proteins?
( these two proteins can be used for screening)
-
-
Q 2. Failure of neural crest migration results in what disease?
-
Q 3. Cystic fibrosis
- mutated gene? what chromosome?
- what is exact mutation? what does it do to normal gene product?
-
Q 3. What is pathophysiology of Cruetzfeldt-Jakob disease?
-
Q 4. Inheritance pattern of PKU?
-
Q 7. What are clinical presentations of gallstone ileus? How is it different from presentations of gallstone in other locations (eg. biliary tree, common bile duct)
-
Q 7. What commonly causes gall stone ileus?
-
Q 7. What is Charcot triad of cholangitis?
-
Q 8. patient with hypertension, hypercholesterolemia, and coronary artery stenosis.
What three medications are normally indicated in this situation? What are reasons?
-
Q 9. How does leptin affects level of POMC (proopiomelanocortin)?
-
Q 10. IgA deficiency is associated with what GI disease?
-
Q 11. What is the strongest predictor for suicide?
-
Q 13. What are two amino acids that are purely ketogenic? (That is, they do not get converted to pyruvate, rather enter TCA cycle right away)
-
Q 14. Where are common sites of extramedullary hematopoiesis? What conditions (2) cause it?
How is it affect bone?
-
- conditions: Beta thalassemia (chipmunk face due to maxillary bone outgrowth), and Rubella (dermal extramedullary hematopoiesis-> blue berry muffin )
-