2/23 UWORLD test # 22

Question 1

Q 1. Bacillus anthracis

• how does it look like on microscope?
• anti-phagocytic virulence factor?
• What are two presentations of anthrax?

Answer 1

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Question 2

Q 2. anti-CCP (cyclic citrullinated peptide) is specific to what disease?

Answer 2

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Question 3

Q 2. How is complement level affected in SLE?

Does this explain nephritic/nephrotic syndrome in kidney? What is this kidney disease? What can you see in LM and EM?

Answer 3

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Question 4

Q 4. What are 4 side effects of lithium?

Answer 4

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Question 5

Q 4. What are side effects of carbamazepine?

A LOT. think as many as possible

Answer 5

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Question 6

Q 5. Explain on-off phenomenon of levodopa. Is this related with drug metabolism or serum drug level?

Answer 6

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Question 7

Q 7. What is bony landmark for lumbar puncture?

Answer 7

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Question 8

Q 7. Which lumbar vertebrae location is targeted by lumbar puncture? why?

Answer 8

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Question 9

Q 8. Describe actinic keratosis. Is this considered as premalignant?

Answer 9

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Question 10

Q 8. Describe atopic dermatitis

Answer 10

No scaly plaque

Question 11

Q 9. For patients suspected with intimate partner violence, what would be the best interview strategies

Answer 11

• ensure privacy: ask parter to leave
• Ask if patient feels safe
• open ended questions with identification of emergency safety plans

Question 12

Q 10. Anatomy: Cardiac catheterization is normally done with cannulation through what artery?
What is the ideal location of puncture for cannulation? What is the most common mortality? How does it happen?

Answer 12

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Question 13

Q 11. Compare: depersonalization disorder vs. dissociative identity disorder

Answer 13

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Question 14

Q 13. What embryological defect will result in tetralogy of Fallot

Answer 14

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Question 15

Q 13. Name three congenital heart diseases that are NOT cyanotic

Answer 15

• ASD
• VSD
• PDA

Question 16

Q 13. What is Eisenmenger syndrome?

Answer 16

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Question 17

Q 14. Calmodulin and MLCK are involved in which muscle type?

Answer 17

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they are NOT involved in skeletal muscle contraction

Question 18

Q 15. Explain pathophysiology of acute vision loss in the setting of elevated ICP

Answer 18

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Question 19

Q 18. McArdle disease

• deficient enzyme
• clinical manifestations

Answer 19

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Question 20

Q 18. Pompe disease

• deficient enzyme
• clinical manifestations

Answer 20

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Question 21

Q 18. Von Gierke disease & Cori disease

• deficient enzyme
• clinical manifestations

Answer 21

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Question 22

Glycogen storage diseases follow what inheritance pattern?

Answer 22

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Question 23

Q 20. At what vertebral level does superior mesenteric artery leave aorta?

Answer 23

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Question 24

Q 20. What is superior mesenteric artery syndrome? What three conditions can cause it?

Answer 24

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Question 25

Q 21. What is tetanus vaccine composed of? Is it safe for pregnant/ immunocompromised patients?

Answer 25

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Question 26

Q 21. Why tetanus vaccine is not given to neonate?

Answer 26

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Question 27

Q 21. Why does tetanus vaccination to pregnant women save neonate getting tetanus

Answer 27

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Question 28

Q 22. Ipratropium - mechanism of action - indication

Answer 28

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Question 29

Q 23. What cranial nerve mediates tongue movement?

Answer 29

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Question 30

Q 24. Will proteinuria be seen in nephritic syndrome?

Answer 30

YES. | urinalysis with +2 protein (mild proteinuira) in nephritic syndrome is pretty common

Question 31

Q 25. Describe two signaling pathways after insulin binding to insulin receptor. How TNF-alpha or counter-regulatory hormones (glucagon, epinephrine) disrupt what part of signaling pathways? (thus induces insulin resistance)

Answer 31

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Question 32

Q 27. Which coagulation factor has the shortest half-life? | How warfarin monitoring is done based on this principle? (FA 406)

Answer 32

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Question 33

Q 27. What is Halothane? What is serious adverse effect of halothane? Abnormal lab findings from this complication?

Answer 33

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Question 34

Q 29. Compare location/characteristics of lung lesion: primary TB vs. secondary TB

Answer 34

- primary TB | - secondary TB

Question 35

Q 31. Zidovudine - mechanism of action - indication - side effects (4)

Answer 35

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Question 36

Q 31. Lopinavir - mechanism of action - indication - side effects (3)

Answer 36

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Question 37

Q 31. Indinavir- what is special side effect of this drug that is not presented in other anti-HIV protease inhibitors?

Answer 37

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Question 38

Q 32. What is structure of myoglobin different from that of hemoglobin? How does this structural difference alter oxygen affinity curve?

Answer 38

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Question 39

Q 33. Metformin - effects - side effects (2) - important consideration before prescription

Answer 39

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Question 40

Q 34. Amlodipine - mechanism of action - indication - one major side effect, why?

Answer 40

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Question 41

Q 36. Cells expressing integrin attaches to extra cellular matrix through what protein?

Answer 41

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Question 42

Q 37. Drug metabolism occurs where in liver?

Answer 42

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Question 43

Q 38. Influenza virus: define and compare difference between "phenotypic mixing" vs. "reassortment"

Answer 43

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Question 44

Q 39. Name sequence of gene mutations in "adenoma to carcinoma sequence" of adenomatous polyps

Answer 44

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Question 45

Q 40. Which immunodeficiency results in fewer and smaller platlets?

Answer 45

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