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UWORLD first pass- week 4 > 2/23 UWORLD test # 22 > Flashcards

2/23 UWORLD test # 22 Flashcards

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1
Q

Q 1. Bacillus anthracis

  • how does it look like on microscope?
  • anti-phagocytic virulence factor?
  • What are two presentations of anthrax?
A

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2
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Q 2. anti-CCP (cyclic citrullinated peptide) is specific to what disease?

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3
Q

Q 2. How is complement level affected in SLE?

Does this explain nephritic/nephrotic syndrome in kidney? What is this kidney disease? What can you see in LM and EM?

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4
Q

Q 4. What are 4 side effects of lithium?

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5
Q

Q 4. What are side effects of carbamazepine?

A LOT. think as many as possible

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6
Q

Q 5. Explain on-off phenomenon of levodopa. Is this related with drug metabolism or serum drug level?

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7
Q

Q 7. What is bony landmark for lumbar puncture?

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8
Q

Q 7. Which lumbar vertebrae location is targeted by lumbar puncture? why?

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9
Q

Q 8. Describe actinic keratosis. Is this considered as premalignant?

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10
Q

Q 8. Describe atopic dermatitis

A

No scaly plaque

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11
Q

Q 9. For patients suspected with intimate partner violence, what would be the best interview strategies

A
  • ensure privacy: ask parter to leave
  • Ask if patient feels safe
  • open ended questions with identification of emergency safety plans
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12
Q

Q 10. Anatomy: Cardiac catheterization is normally done with cannulation through what artery?
What is the ideal location of puncture for cannulation? What is the most common mortality? How does it happen?

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13
Q

Q 11. Compare: depersonalization disorder vs. dissociative identity disorder

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14
Q

Q 13. What embryological defect will result in tetralogy of Fallot

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15
Q

Q 13. Name three congenital heart diseases that are NOT cyanotic

A
  • ASD
  • VSD
  • PDA
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16
Q

Q 13. What is Eisenmenger syndrome?

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17
Q

Q 14. Calmodulin and MLCK are involved in which muscle type?

A

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they are NOT involved in skeletal muscle contraction

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18
Q

Q 15. Explain pathophysiology of acute vision loss in the setting of elevated ICP

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19
Q

Q 18. McArdle disease

  • deficient enzyme
  • clinical manifestations
A

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20
Q

Q 18. Pompe disease

  • deficient enzyme
  • clinical manifestations
A

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21
Q

Q 18. Von Gierke disease & Cori disease

  • deficient enzyme
  • clinical manifestations
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22
Q

Glycogen storage diseases follow what inheritance pattern?

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23
Q

Q 20. At what vertebral level does superior mesenteric artery leave aorta?

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24
Q

Q 20. What is superior mesenteric artery syndrome? What three conditions can cause it?

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25
Q

Q 21. What is tetanus vaccine composed of? Is it safe for pregnant/ immunocompromised patients?

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26
Q

Q 21. Why tetanus vaccine is not given to neonate?

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27
Q

Q 21. Why does tetanus vaccination to pregnant women save neonate getting tetanus

A

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28
Q

Q 22. Ipratropium

  • mechanism of action
  • indication
A

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29
Q

Q 23. What cranial nerve mediates tongue movement?

A

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30
Q

Q 24. Will proteinuria be seen in nephritic syndrome?

A

YES.

urinalysis with +2 protein (mild proteinuira) in nephritic syndrome is pretty common

31
Q

Q 25. Describe two signaling pathways after insulin binding to insulin receptor.
How TNF-alpha or counter-regulatory hormones (glucagon, epinephrine) disrupt what part of signaling pathways? (thus induces insulin resistance)

A

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32
Q

Q 27. Which coagulation factor has the shortest half-life?

How warfarin monitoring is done based on this principle? (FA 406)

A

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33
Q

Q 27. What is Halothane? What is serious adverse effect of halothane? Abnormal lab findings from this complication?

A

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34
Q

Q 29. Compare location/characteristics of lung lesion: primary TB vs. secondary TB

A
  • primary TB

- secondary TB

35
Q

Q 31. Zidovudine

  • mechanism of action
  • indication
  • side effects (4)
A

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36
Q

Q 31. Lopinavir

  • mechanism of action
  • indication
  • side effects (3)
A

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37
Q

Q 31. Indinavir- what is special side effect of this drug that is not presented in other anti-HIV protease inhibitors?

A

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38
Q

Q 32. What is structure of myoglobin different from that of hemoglobin? How does this structural difference alter oxygen affinity curve?

A

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39
Q

Q 33. Metformin

  • effects
  • side effects (2)
  • important consideration before prescription
A

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40
Q

Q 34. Amlodipine

  • mechanism of action
  • indication
  • one major side effect, why?
A

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41
Q

Q 36. Cells expressing integrin attaches to extra cellular matrix through what protein?

A

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42
Q

Q 37. Drug metabolism occurs where in liver?

A

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43
Q

Q 38. Influenza virus: define and compare difference between “phenotypic mixing” vs. “reassortment”

A

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44
Q

Q 39. Name sequence of gene mutations in “adenoma to carcinoma sequence” of adenomatous polyps

A

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45
Q

Q 40. Which immunodeficiency results in fewer and smaller platlets?

A

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UWORLD first pass- week 4 (7 decks)

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