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UWORLD first pass- week 4 > 2/22 UWORLD test # 21 > Flashcards

2/22 UWORLD test # 21 Flashcards

1
Q

Q 2. Which structures (2) drain into deep inguinal lymph node?

A

  • These are all derived from genital tubercle!
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2
Q

Q 2. Is para-aortic lymph node retroperitoneal or intraperitoneal?

A

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3
Q

Q 3. Kinesin vs. Dynein: compare directionality of movement of these motor protein

  • How this relates to HSV-1 movement- from trigeminal nerve to skin/ mucosa ( or from skin/mucosa to trigeminal nerve)
A

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4
Q

List three examples of viruses that reside in neuron and migrates. From which region of nerve to where?

A
  • HSV-1
    : reside in trigeminal nerve during latency, move to skin/mucosa (anterograde) under stressed condition
  • VZV
    : reside in dorsal root or trigeminal ganglia during latency, move to skin
  • Rabies
    : Bind to Ach receptor (nicotinic), migrate through motor neuron up to CNS (purkinje cells and pyramidal cells in hippocampus)
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5
Q

Q 4. Duchenne muscle dystrophy

  • mutation on what gene, function of this gene
  • nature of mutation (FA 52)
  • inheritance pattern
  • phenotype
  • onset & by what age patient will be on wheelchair?
  • physical exam findings (2)
A 
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-
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-
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6
Q

Duchenne muscle dystrophy vs. Becker muscle dystrophy

  1. mutated gene/ nature of mutation
  2. onset
  3. severity
A

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7
Q

Q 6. Explain the mechanism regarding how mycobacterium activates Th1 and subsequent release of INF-gamma
(through which cytokine?)

A

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8
Q

Q 8. Lactose intolerance

  • Which enzyme is missing in lactose intolerance?
  • Where is this enzyme located?
  • Describe phenotype of lactose intolerance
A

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9
Q

Q 8. Give two examples of secondary lactose intolerance

A

-

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10
Q

Q 9. Familial hypercholesterolemia

  • lab finding, why this occurs?
  • inheritance pattern
  • phenotypes
A

-

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11
Q

Q 11. Diagnostic criteria for bipolar 1 disorder?

A

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12
Q

Q 11. Diagnostic criteria for bipolar 1 with psychotic feature?

A

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13
Q

Q 11. Diagnostic criteria for bipolar 2 disorder?

A

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14
Q

Diagnostic criteria for cyclothymic disorder?

A

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15
Q

Q 13. What is the first step for addressing medical error?

A

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16
Q

Q 14. What are two transporters responsible for removal of cytoplasmic Ca2+ during myocyte relaxation. How these two transporters different from each other?

A

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17
Q

Q 17. Anatomy: supracondylar humeral fracture- anteromedial fracture vs. anterolateral fracture: which structure is vulnerable to get disrupted in each case?

A
  • anteromedial fracture

- anterolateral fracture

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18
Q

Q 17. In which scenario will biceps tendon damage occur?

think where biceps insertions are

A

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19
Q

Q 17. Where is ulnar nerve located with respect to medial epicondyle? in which scenario will it get damaged?

A

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20
Q

Q 18. Leukocyte count in leukocyte adhesion deficiency?

A

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21
Q

Q 18. What is allantosis (embryological structure)?

  • What embryological structure forms it?
  • What another embryological structure does it become?
  • What is its fate? (does it regress? or become final structure?)
A

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22
Q

Q 18. Describe four possible scenarios of abnormal urachus closure. What are clinical features for each case?
( one extra scenario is on FA 567, not uworld)

A

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-

23
Q

Q 19. Describe where exactly ACL and PCL insertions are

A
  • ACL

- PCL

24
Q

Q 21. Colchicine

  • mechanism of action
  • indication
  • side effects
A

-

25
Q

Q 21. Why uric acid level managing drugs (allopurinol, probenecid) are not indicated in acute gout attack?

A

-

26
Q

Q 21. What is side effect of probenecid?

A

-

27
Q

Q 22. gram negative rod, oxidase positive, pigment on medium. what is this bug? Describe name/ color of this pigment

A

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28
Q

Q 22. What is “hot tub folliculitis”? which infection can cause it?

A

-

29
Q

Q 24. ulcerative genital lesion: give two examples of each

  • painful
  • non-painful
A
  • painful

- non-painful

30
Q

Q 25. How well does giant arthritis respond to prednisone?

A

-

31
Q

Q 25. Giant cell arthritis is associated with what myalgia condition?

A

-

32
Q

Q 26. Explain why high flow oxygen is NOT indicated for treating COPD. (there are 3 possible mechanisms) What is this phenomenon called?

A

-

33
Q

Q 27. In healthy person, will ACEI cause significant reduction in GFR? In what renal condition will ACEI causes significant GFR reduction?

A

With renal artery stenosis, maintenance GFR is largely dependent on AngII. So ACEI will cause significant reduction.

For healthy person, AngII also plays role in GFR maintenance, but blocking of AngII by ACEI will not significantly drop GFR as blood entering to renal artery is still significantly higher than renal artery stenosis

34
Q

Q 28. Will Barrett’s esophagus cause symptoms (like heartburn, dysphagia)?

A

No.
Barrett’s esophagus (intestinal metaplasia) is the body’s normal response to protect esophagus. It will present with pain UNLESS it progresses to adenocarcinoma

35
Q

Q 29. What is bosentan? it is indicated for what? what is side effect?

A

-

36
Q

Q 29. List three indications of ACEI

A

-
- congestive HF (decrease mortality only, no dramatic symptom relief)
-

37
Q

Q 29. Disruption of which gene is associated with hereditary pulmonary hypertension? what is function of this gene?

A

-

38
Q

Q 32. What intrinsic property of cardiomyocyte is impaired in diastolic HF? With this property change explain what happened for

  • end-diastolic volume
  • end- diastolic pressure
  • systolic ejection fraction
A

-

39
Q

Q 33. Mifepristone

  • mechanism of action
  • indication
A

-

40
Q

Q 33. Misoprostol

  • mechanism of action
  • indications (3)
A

-

41
Q

Q 37. How liver biopsy looks like in HepB hepatitis?

A

-

42
Q

Q 37. How liver biopsy looks like in alcoholic steatohepatitis?

A

-

43
Q

Q 38. Directionality of airflow in

  • positive airway pressure
  • negative airway pressure
A
  • positive airway pressure: air flow out from lung

- negative airway pressure: air flow into lung

44
Q

Q 38. Which capacity tells the volume of lung in which chest wall recoil equals to lung recoil (neither entry or exit of air)

A

-

45
Q

Q 38. At equilibrium between lung elastic recoil is equal to chest wall elastic recoil, what is the approximate value of intraplerual pressure (also is it positive or negative?) How does this explain pneumothorax after stabbing?

A

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46
Q

Q 39. trastuzumab

  • mechanism of action
  • indication
A

-

47
Q

Q 39. bevacizumab

  • mechanism of action
  • indications (2)
A

-

48
Q

Q 40. Define polygenic inheritance. What are examples of diseases that follow this pattern?

A

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UWORLD first pass- week 4 (7 decks)

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