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UWORLD first pass- week 3 > 2/18 UWORLD test # 18 > Flashcards

2/18 UWORLD test # 18 Flashcards

1
Q

Q 1. What protein consists of gap junction?

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2
Q

Q 1. What protein consists of tight junction?

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3
Q

Q 1. What protein consists of hemidesomosome?

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4
Q

Q 1. What protein consists of desomosome?

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5
Q

Q 1. What protein consists of adherens junction?

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6
Q

Q 2. What is paresthesia? seizure at what part of brain can result it?

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7
Q

Q 3. Difference in opthalmoscope finding - hypertensive retinal hemorrhage vs. central retinal artery occulusion

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8
Q

Q 4. What is 3 base sequence on mRNA that plays key role in translation initiation process? Where is it located?

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9
Q

Q 6. How most virus obtain envelop? Which virus has an exception for this rule? How does it obtain it?
(NOT on sketchy or first aid)

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10
Q

Q 7. PMI ( point of maximal impulse) in Right fifth intercoastal space. what is going on?

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11
Q

Q 7. Other than situs inversus, what other things can also happen in Kartagener syndrome? (3)

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12
Q

Q 8. What enzyme is deficient in PKU (phenylketonuira)? inheritance pattern?

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13
Q

Q 10. What is hallmark of generalized anxiety disorder?

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14
Q

Q 11. What are underlying medical conditions that can cause anxiety (5)?

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15
Q

Q 12. Target of trimethoprim? What about sulfonamide?

A
  • TMP

- SMX

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16
Q

Q 14. With oxygen binding to hemoglobin, what does hemoglobin release? what does erythrocyte release?

A
  • Hb

- Erythrocyte

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17
Q

Q 15. What local metabolites that act as vasodilator during exercise (5)?
hint: mnemonic - FA 280

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18
Q

Q 16. What is normal Aa gradient value?

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19
Q

Q 16. Hypoxemia- examples?

  1. normal Aa gradient (2)
  2. High Aa gradient (3)
A

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20
Q

FA 614. Hypoxia vs. Hypoxemia

  1. definition
  2. examples
A

Hypoxia
1.
2.

Hypoxemia
1.
2.

21
Q

FA 613. Formula for O2 delivery to tissues?

A

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22
Q

Q 17. Compare TLC (total lung capacity) in chronic bronchitis vs. emphysema

A
  • chronic bronchitis

- emphysema

23
Q

Q 18. What are retroperitoneal organs?

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24
Q

Q 18. In terms of anatomic location (retroperitoneal vs intrapertoneal), different parts of pancreas / colon / duodenum are located differently. how?

A
  • retroperitoneal
    pancreas:
    colon:
    duodenum:
  • intraperitoneal
    pancreas:
    colon:
    duodenum:
25
Q

Q 19. MDR1 (multi-drug resistance) gene

  • what protein does it encode? what is its function?
  • which cells (3) normally express it? explain physiology
  • how MDR1 expression impacts tumor cells?
A

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26
Q

Q 20. Beta blockers (-olol)

  • which ones are beta 1 selective? which ones are non-selective? ( There is easy way to remember this by order of alphabet. Give example of each)
  • one drug ending -olol are not beta blocker. What is this?
A

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27
Q

Q 21. Trypanosoma cruzi

  • clinical manifestations (3), what is name of disease that encompass all these three phenotypes
  • transmission
  • treatment (2 drugs)
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28
Q

Q 22. Clinical features (5) of mononucleosis?

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29
Q

Q 23. Glomerular basement membrane disruptions and fibrin deposition in electron microscopy?

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30
Q

Q 23. Diffuse capillary wall thickening in light microscopy?

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31
Q

Q 24. Most common cause of tubal factor infertility?

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32
Q

Q 24. What is treatment regimen for PID? why? what is consequence of inadequate treatment?

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33
Q

Q 25. Describe phenotype of 11-Beta hydroxylase deficiency.

vs. 17- alpha deficiency: similarity vs. difference- especially regarding external genitalia

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34
Q

Q 26. Given Vd and CL, what is formula of half-life?

no explanation for this formula, just gotta memorize it

A

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35
Q

Q 27. Which cell express CD16?

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36
Q

Which cell express CD14?

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37
Q

Which cell express CD25?

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38
Q

Common fungi/parasite infections in

  1. B cell deficiency
  2. T cell deficiency
  3. Neutrophil deficiency
  4. complement deficiency
A
  • B cell deficiency
  • T cell deficiency
  • Neutrophil deficiency
  • Complement deficiency
39
Q

Q 29. Give three drug names of Dihydropyridine CCBs?

hint: what is common suffix?

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40
Q

Q 31. Two specific findings of Grave’s disease. What is pathophysiology for these findings?

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41
Q

Q 32. Will aplastic anemia result in splenomegaly?

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42
Q

Q 33. Describe how Gq second messenger system works. (what intermediates? what is final effect?)

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43
Q

Describe how Gs/Gi second messenger system works

: intermediates, final effect

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44
Q

Q 36. Polyarthritis nodosa is associated with what infection?

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45
Q

Q 37. Describe morphologic feature of artery in polyarthritis nodosa

  • what size artery
  • characteristic morphology
  • mediated by necrotic process
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46
Q

Q 37. Describe morphologic feature of artery in Buerger’s disease (thromboangitis obliterans)

A

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47
Q

Polyarthritis nodosa

  • common organ affected
  • organ saved
  • treatment
A

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48
Q

Q 38. Damage to levator ani muscle results in what type of urinary incontinence? What is treatment?

A

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UWORLD first pass- week 3 (4 decks)

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