2/18 UWORLD test # 18

Question 1

Q 1. What protein consists of gap junction?

Answer 1

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Question 2

Q 1. What protein consists of tight junction?

Answer 2

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Question 3

Q 1. What protein consists of hemidesomosome?

Answer 3

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Question 4

Q 1. What protein consists of desomosome?

Answer 4

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Question 5

Q 1. What protein consists of adherens junction?

Answer 5

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Question 6

Q 2. What is paresthesia? seizure at what part of brain can result it?

Answer 6

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Question 7

Q 3. Difference in opthalmoscope finding - hypertensive retinal hemorrhage vs. central retinal artery occulusion

Answer 7

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Question 8

Q 4. What is 3 base sequence on mRNA that plays key role in translation initiation process? Where is it located?

Answer 8

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Question 9

Q 6. How most virus obtain envelop? Which virus has an exception for this rule? How does it obtain it?
(NOT on sketchy or first aid)

Answer 9

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Question 10

Q 7. PMI ( point of maximal impulse) in Right fifth intercoastal space. what is going on?

Answer 10

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Question 11

Q 7. Other than situs inversus, what other things can also happen in Kartagener syndrome? (3)

Answer 11

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Question 12

Q 8. What enzyme is deficient in PKU (phenylketonuira)? inheritance pattern?

Answer 12

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Question 13

Q 10. What is hallmark of generalized anxiety disorder?

Answer 13

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Question 14

Q 11. What are underlying medical conditions that can cause anxiety (5)?

Answer 14

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Question 15

Q 12. Target of trimethoprim? What about sulfonamide?

Answer 15

• TMP

- SMX

Question 16

Q 14. With oxygen binding to hemoglobin, what does hemoglobin release? what does erythrocyte release?

Answer 16

• Hb

- Erythrocyte

Question 17

Q 15. What local metabolites that act as vasodilator during exercise (5)?
hint: mnemonic - FA 280

Answer 17

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Question 18

Q 16. What is normal Aa gradient value?

Answer 18

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Question 19

Q 16. Hypoxemia- examples?

1. normal Aa gradient (2)
2. High Aa gradient (3)

Answer 19

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Question 20

FA 614. Hypoxia vs. Hypoxemia

1. definition
2. examples

Answer 20

Hypoxia
1.
2.

Hypoxemia
1.
2.

Question 21

FA 613. Formula for O2 delivery to tissues?

Answer 21

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Question 22

Q 17. Compare TLC (total lung capacity) in chronic bronchitis vs. emphysema

Answer 22

• chronic bronchitis

- emphysema

Question 23

Q 18. What are retroperitoneal organs?

Answer 23

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Question 24

Q 18. In terms of anatomic location (retroperitoneal vs intrapertoneal), different parts of pancreas / colon / duodenum are located differently. how?

Answer 24

• retroperitoneal
  pancreas:
  colon:
  duodenum:
• intraperitoneal
  pancreas:
  colon:
  duodenum:

Question 25

Q 19. MDR1 (multi-drug resistance) gene - what protein does it encode? what is its function? - which cells (3) normally express it? explain physiology - how MDR1 expression impacts tumor cells?

Answer 25

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Question 26

Q 20. Beta blockers (-olol) - which ones are beta 1 selective? which ones are non-selective? ( There is easy way to remember this by order of alphabet. Give example of each) - one drug ending -olol are not beta blocker. What is this?

Answer 26

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Question 27

Q 21. Trypanosoma cruzi - clinical manifestations (3), what is name of disease that encompass all these three phenotypes - transmission - treatment (2 drugs)

Answer 27

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Question 28

Q 22. Clinical features (5) of mononucleosis?

Answer 28

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Question 29

Q 23. Glomerular basement membrane disruptions and fibrin deposition in electron microscopy?

Answer 29

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Question 30

Q 23. Diffuse capillary wall thickening in light microscopy?

Answer 30

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Question 31

Q 24. Most common cause of tubal factor infertility?

Answer 31

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Question 32

Q 24. What is treatment regimen for PID? why? what is consequence of inadequate treatment?

Answer 32

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Question 33

Q 25. Describe phenotype of 11-Beta hydroxylase deficiency. | vs. 17- alpha deficiency: similarity vs. difference- especially regarding external genitalia

Answer 33

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Question 34

Q 26. Given Vd and CL, what is formula of half-life? | no explanation for this formula, just gotta memorize it

Answer 34

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Question 35

Q 27. Which cell express CD16?

Answer 35

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Question 36

Which cell express CD14?

Answer 36

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Question 37

Which cell express CD25?

Answer 37

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Question 38

Common fungi/parasite infections in 1. B cell deficiency 2. T cell deficiency 3. Neutrophil deficiency 4. complement deficiency

Answer 38

- B cell deficiency - T cell deficiency - Neutrophil deficiency - Complement deficiency

Question 39

Q 29. Give three drug names of Dihydropyridine CCBs? | hint: what is common suffix?

Answer 39

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Question 40

Q 31. Two specific findings of Grave's disease. What is pathophysiology for these findings?

Answer 40

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Question 41

Q 32. Will aplastic anemia result in splenomegaly?

Answer 41

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Question 42

Q 33. Describe how Gq second messenger system works. (what intermediates? what is final effect?)

Answer 42

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Question 43

Describe how Gs/Gi second messenger system works | : intermediates, final effect

Answer 43

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Question 44

Q 36. Polyarthritis nodosa is associated with what infection?

Answer 44

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Question 45

Q 37. Describe morphologic feature of artery in polyarthritis nodosa - what size artery - characteristic morphology - mediated by necrotic process

Answer 45

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Question 46

Q 37. Describe morphologic feature of artery in Buerger's disease (thromboangitis obliterans)

Answer 46

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Question 47

Polyarthritis nodosa - common organ affected - organ saved - treatment

Answer 47

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Question 48

Q 38. Damage to levator ani muscle results in what type of urinary incontinence? What is treatment?

Answer 48

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