1y- Control of programmed cell death (apoptosis) Flashcards
1
Q
What is apoptosis triggered by?
A
Cell death signals that can be external or internal
2
Q
What is an example of an external death signal?
A
The production of death signal molecules from lymphocytes
3
Q
What is an example of an internal death signal?
A
DNA damage
4
Q
What does an internal death signal resulting from DNA damage cause the activation of?
A
p53 tumour-suppressor protein
5
Q
What do both types of death signal (external and internal) result in?
A
The activation of caspases (types of protease enzymes) that cause the destruction of the cell
6
Q
Why is apoptosis essential during the development of an organism?
A
To remove cells no longer required as development progresses or during metamorphosis
7
Q
When may cells initiate apoptosis?
A
In the absence of growth factors
