1st generation antipsychotics (TYPICAL) Flashcards
1
Q
MoA
A
Blocks post-synaptic dopamine D2 receptors in the brain
2
Q
Why are typical antipsychotics not preferred?
A
- More extrapyramidal symptoms (EPS)
- More hyperprolactinaemia
3
Q
Phenothiazines
A
Hepatotoxic & acute dystonic reactions
Split into groups (1, 2 & 3)
4
Q
Group 1
A
MOST SEDATIVE
- Chlorpromazine (contact sensitisation)
- Levomepromazine
- Promazine (used OTC as sedative)
5
Q
Group 2
A
LEAST EPS
- Pericyazine
6
Q
Group 3
A
MOST EPS
- Fluphenazine
- Perphenazine
- Prochlorperazine
- Trifluoperazine
7
Q
Butyrophenones
A
Haloperidol
- Most EPS
- QT interval prolongation
8
Q
Thioxanthenes
A
Flupentixol
Zuclopenthixol
9
Q
Flupentixol
A
Alerting effect
Should not take in evening
10
Q
Zuclopenthixol
A
Depot preparation
Used in agitated/aggressive patients
More effective in preventing relapse
11
Q
Others
A
Pimozide (QT interval prolongation
Sulpiride
Loxapine (bronchospasms)
