1A - Innate Immunity Flashcards
infectious diseases are caused by
Bacteria, Virus, Prions, Protozoa, Fungi, Parasites
non-infectious diseases are caused by
Nutritional, metabolic, trauma, toxic materials, congenital defects
a contagious disease
Animal to animal transfer
noncontagous disease
Environment to animal transfer
the infectious disease process
◦ Enter host (invade) ◦ Multiply ◦ Evade host (hide) ◦ Harm host
the determinants of disease (triad of disease determinants)
Host, Agent, Environment
Host (determinants of disease)
genotype, species, breed, age, sex, social and occupational factors
Agent (determinants of disease)
Pathogenicity and virulence
Environment (determinants of disease)
location, climate, housing, management, feeding, stress
portals of entry (of pathogens)
Ingestion, Inhalation, Cutaneous penetration, Ascending infection
direct transmission
cough, touch, bites, grooming, licking, ingestion
vector
organisms that transmit an infectious agent from one animal to another
fomites
inanimate objects that transmit a particular disease or parasite from one animal to another
indirect transmission
transmission via vector or fomite
epidemic
rate of new cases in a population is greater than expected
endemic
disease is maintained at a relatively constant rate in the population without the need for external input
pandemic
epidemic of worldwide distribution
classification of disease by spread
transmission
commensalism
relationship in which neither parties are harmed
mutualism
relationship in which both benefit
parasitism
relationship in which one lives at the expens of other
virulence and pathogenicity can be used to describe
the ability of the agent to cause disease; used interchangably
virulence
the degree of harm the organism causes
pathogenicity
refers to the ability of an organism to cause disease
infectious dose
minimum number of organisms required to cause infection
factors that effect infectious dose
age, sex, immune status, pregnancy status
types of pathogens
obligate, opportunistic
obligate pathogens
associated only with disease
opportunistic pathogens
potential pathogens; part of the norma flora until oportunity strikes via host becoming immunocompromised
frontal assault pathogenic microbes
(acute)‣ Short incubation ‣ Rapid clinical signs ‣ Intimate transmission ‣ Ex - many childhood diseases, parvovirus in dogs, salmonellosis, acute mastitis, COVID
stealth assault pathogenic microbes
(insidious) ‣ Incubation lengthy ‣ Slow onset of signs ‣ May have environmental transmission ‣ Ex - Bovine Johne’s Disease, Tuberculosis, Chronic wasting disease
host
describe the lifecycle of hlminths and protozoa
definitive host
in which the infectious agent reaches sexual maturity or replicates
intermediate host
essential part of the parasite lifecycle; temporary environment for development
reservoir host
harbors pathogens that infect others; host does not demonstrate clinical signs of the disease
dead-end host
can get infected but is unlikely to pass the agent to another host