1.9b Cell-mediated Immunity Flashcards

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1
Q

Most antigens that stimulate cell-mediated immunity are (intracellular/extracellular) in nature?

A

Intracellular

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2
Q

Antigen receptors react specifically to many antigens. (True or false)

A

False!

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2
Q

Macrophages’ phagocytic ability is increased by (2)?

A

ingestion of antigenic material

cytokines

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3
Q

Helper T cell is also known as

A

CD4+ cells

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3
Q

Td cell is associated to what?

A. Planting of rice

B. Watering of plants

C. Plantsa-ing of clothes

D. Transplant rejection

A

Duh!! Ewan ko na lang kung mali ka pa dito. :)

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3
Q

Are NK cells phagocytic?

A

No.

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3
Q

Type of NK cell receptor that recognizes HLA-B or HLA-C molecules

A

KIRS

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4
Q

Who has the greatest ability to make new T cell?

A. Ate Mariz

B. Ate Ecar

C. Doc Torres

D. Junibi

A

D. Junibaby :)

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4
Q

Td cells are mostly what kind of Tcell?

A

Th cell

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4
Q

Natural Killer Cells express antigen-specific receptors (True or False)

A

False!

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5
Q

MHC I can be found in?

A

All nucleated cells of the body

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7
Q

IL-1 is for?

IL-2 is for?

(role in cell-mediated immunity)

A

IL-1 = activation of Th cell

IL-2 = proliferation and differentiation into mature Th cell

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8
Q

Main function of thymic factors.

A

For maturation and maintenance of T cell.

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8
Q

Two types of surface receptors found in NK cells.

A

Lectin-like NK-cell receptors

Killer Ig-like receptors

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9
Q

MHC II can be found where?

A

Macrophages and B cells

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11
Q

Released by cytotoxic Tcell that is responsible for the formation of PORES in the membrane of the target foreign body.

A

Perforin

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11
Q

Turned off when an antigen is no longer present.

A

Seppressor T cells ( Ts cells)

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12
Q

Lytic activity of NK cells is enhanced by?

A

High levels of IFN-alpha and IFN-beta

13
Q

Mechanism by which Tcell+Ag receptors are stimulated to be differentiated into the effector Tcell that carry out cell-mediated immunity

A

Clonal Selection.

14
Q
A
16
Q

What are responsible for secondary immune response?

A

Memory cells

18
Q

Plays an essential role in bacterial escape from phagosome into the cytoplasm where the pathogen multiplies more efficiently

A

CytoLLO

20
Q

These are large, granular lymphocytes mophologically related to T cell?

A

NK cells

21
Q

Cells which ingest and process the antigen then diplay fragments of the antigen on the cell surface

A

APCs

22
Q

Cell-mediated immunity is transferrable to fetus via placenta. (True/False)

A

False!!!

23
Q

Not well understood.

A

Life of a med student. :(

24
Q

Phagocytic cell that are usually found in the resting state

A

KRYSTEL!!!

(Macrophages)

25
Q

T cells migrate where after differentiation in the thymus gland?

A

Not in Texas.

Not in Las Pinas.

In lymphoid tissue!

26
Q

What is the key cellular component of cell-mediated immunity?

A

T-rex?

T-test?

T-cells!!!! :)

28
Q

Lectin-like NK-cell receptors bind to (carbs or proteins)?

A

proteins!

29
Q

When a Th cell receptor binds to the MHC-Ag complex, APC is stimulated to secrete what?

A

IL-1

30
Q

Cells for which cell-mediated immunity was originally named.

A

Delayed Hypersensitivity Cell (Td cell)

32
Q

Most important virulence determinant of L. monocytogenes.

A

CytoLLO

33
Q

Consists of cell-surface proteins unique to each individual and indicate self molecules

A

MHC

34
Q

Th : MHC class ?

Cytotoxic Tcell : MHC class ?

A

Always remember:

Helper Tcell : CD4: MHC class 2: 4 x 2 =8

Cytotoxic Tcell: CD8: MHC class 1: 8 x 1 = 8

36
Q

APCs are composed primarily of what?

A. Apple

B. Pineapple

C. Citrus

D. Answer the question!

A

Macrophages

37
Q

They attack large parasites.

A

NK cells

38
Q

Cell-med immunity can stimulate NK cells, macrophages, and other leukocytes to kill antibody-coated cells that are too large to be phagocytosed, in the presence of what?

A

Antibodies

39
Q

Type of CD4+ that is responsible for the up-regulation of humoral responses.

A

Th2 cell

40
Q

NK cells play a role in ADCC. What is ADCC?

A

Antibody-dependent cellular cytotoxicity

41
Q

Th1 is for what?

A

Up regulation of cellular responses (NK cell, Tcell, Bcell, and macrophage function)

42
Q

To maintain the effectiveness of cell-mediated immunity, it generally requires what?

A

Presence of Ag

43
Q

T cells develop from (what type of cell?) in the (what) and they mature (where? Clue: T-t-t-cell).

A

What type: stem cell

in the what: bone marrow

where: thymus gland