1.9b Cell-mediated Immunity Flashcards
Most antigens that stimulate cell-mediated immunity are (intracellular/extracellular) in nature?
Intracellular
Antigen receptors react specifically to many antigens. (True or false)
False!
Macrophages’ phagocytic ability is increased by (2)?
ingestion of antigenic material
cytokines
Helper T cell is also known as
CD4+ cells
Td cell is associated to what?
A. Planting of rice
B. Watering of plants
C. Plantsa-ing of clothes
D. Transplant rejection
Duh!! Ewan ko na lang kung mali ka pa dito. :)
Are NK cells phagocytic?
No.
Type of NK cell receptor that recognizes HLA-B or HLA-C molecules
KIRS
Who has the greatest ability to make new T cell?
A. Ate Mariz
B. Ate Ecar
C. Doc Torres
D. Junibi
D. Junibaby :)
Td cells are mostly what kind of Tcell?
Th cell
Natural Killer Cells express antigen-specific receptors (True or False)
False!
MHC I can be found in?
All nucleated cells of the body
IL-1 is for?
IL-2 is for?
(role in cell-mediated immunity)
IL-1 = activation of Th cell
IL-2 = proliferation and differentiation into mature Th cell
Main function of thymic factors.
For maturation and maintenance of T cell.
Two types of surface receptors found in NK cells.
Lectin-like NK-cell receptors
Killer Ig-like receptors
MHC II can be found where?
Macrophages and B cells
Released by cytotoxic Tcell that is responsible for the formation of PORES in the membrane of the target foreign body.
Perforin
Turned off when an antigen is no longer present.
Seppressor T cells ( Ts cells)
Lytic activity of NK cells is enhanced by?
High levels of IFN-alpha and IFN-beta
Mechanism by which Tcell+Ag receptors are stimulated to be differentiated into the effector Tcell that carry out cell-mediated immunity
Clonal Selection.
What are responsible for secondary immune response?
Memory cells
Plays an essential role in bacterial escape from phagosome into the cytoplasm where the pathogen multiplies more efficiently
CytoLLO
These are large, granular lymphocytes mophologically related to T cell?
NK cells
Cells which ingest and process the antigen then diplay fragments of the antigen on the cell surface
APCs
Cell-mediated immunity is transferrable to fetus via placenta. (True/False)
False!!!
Not well understood.
Life of a med student. :(
Phagocytic cell that are usually found in the resting state
KRYSTEL!!!
(Macrophages)
T cells migrate where after differentiation in the thymus gland?
Not in Texas.
Not in Las Pinas.
In lymphoid tissue!
What is the key cellular component of cell-mediated immunity?
T-rex?
T-test?
T-cells!!!! :)
Lectin-like NK-cell receptors bind to (carbs or proteins)?
proteins!
When a Th cell receptor binds to the MHC-Ag complex, APC is stimulated to secrete what?
IL-1
Cells for which cell-mediated immunity was originally named.
Delayed Hypersensitivity Cell (Td cell)
Most important virulence determinant of L. monocytogenes.
CytoLLO
Consists of cell-surface proteins unique to each individual and indicate self molecules
MHC
Th : MHC class ?
Cytotoxic Tcell : MHC class ?
Always remember:
Helper Tcell : CD4: MHC class 2: 4 x 2 =8
Cytotoxic Tcell: CD8: MHC class 1: 8 x 1 = 8
APCs are composed primarily of what?
A. Apple
B. Pineapple
C. Citrus
D. Answer the question!
Macrophages
They attack large parasites.
NK cells
Cell-med immunity can stimulate NK cells, macrophages, and other leukocytes to kill antibody-coated cells that are too large to be phagocytosed, in the presence of what?
Antibodies
Type of CD4+ that is responsible for the up-regulation of humoral responses.
Th2 cell
NK cells play a role in ADCC. What is ADCC?
Antibody-dependent cellular cytotoxicity
Th1 is for what?
Up regulation of cellular responses (NK cell, Tcell, Bcell, and macrophage function)
To maintain the effectiveness of cell-mediated immunity, it generally requires what?
Presence of Ag
T cells develop from (what type of cell?) in the (what) and they mature (where? Clue: T-t-t-cell).
What type: stem cell
in the what: bone marrow
where: thymus gland
