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MICROBIOLOGY 1.0 > 1.9a Humoral Immunity > Flashcards

1.9a Humoral Immunity Flashcards

1
Q

smallest unit of a complex antigen that is capable of binding to an Ab

A

epitope

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2
Q

What is/are the product in the ffg: 1. Papain + Ig 2. Pepsin + Ig

A
  1. 2 identical Fab regions and 1 Fc region 2. F(ab’)2 (divalent Antigen binding sites)
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2
Q

Ig that is primarily found on the Bcell surface

A

IgD

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3
Q

an Ig that has an Fc potion already bound even before antigen binding.

A

IgE

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3
Q

Phases of Primary Immunogen clearance

A

Equilibrium Phase Catabolic Phase Immune elimination phase

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4
Q

region in the Ig structure that offers great flexibility

A

Hinge region

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5
Q

what is the immunogenic component in the hapten-carrier conjugate complex?

A

Carriers (not the hapten)

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5
Q

T/F. IgD fixes complement cascade

A

False

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6
Q

relation of immunogenicity to size of immunogen

A

Direct

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6
Q

what type of Antigen has no Equilibrium phase?

A

Particulate/Insoluble Antigens

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7
Q

2nd most abundant serum Ig

A

IgA

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8
Q

relation of immunogenicity to chemical composition simplicity of immunogen

A

Indirect

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8
Q

which cell responds to small antigenic size of 4-8 residues only

A

B cells (T cells: 8-15 residues)

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8
Q

cells that cannot recognize free peptides/antigens

A

T cells (require MHC from APC’s)

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9
Q

main Ig produced early in th eprimary immune response

A

IgM

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10
Q

2 effector functions of immunoglobulins

A

Complement fixation bind to various cell types

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11
Q

Factors affecting the immunogenicity

A

(from immunogens) Foreignness Size Chemical Composition Physical Form Degradability (from biological System) Genectic Factor Age

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13
Q

what cell facilitates Ab secretion?

A

Plasma cells

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15
Q

Active or Passive Immunity. More Powerful.

A

Passive immunity

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16
Q

When does the Antibody in the serum detected? A. After Equilibrium Phase B. Before Catabolic Phase C. During Catabolic Phase D. After Immune Elimination phase

A

D. After Immune Elimination phase

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17
Q

Active or Passive Immunity. Long term

A

Active immunity

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18
Q

any particle that induces a specific immune response

A

Antigen

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18
Q

IgG subclass that cannot pass through the placenta

A

IgG2

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19
Q

Which biomolecule is the best immunogens?

A

Proteins (Proteins>CHO>Nucleic acid>lipids

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20
Q

Active or Passive Immunity Amplification of plasma cells

A

Active immunity

21
Q

are substances that can enhance the immune response

22
Q

type of T-independent Ag that can activate polyclonal B cells

22
Q

An Ig with Alpha as heavy chain can have both kappa and Lambda as light chains

A

False if in one Ig True if different Ig

23
Q

What is the major serum Ig?

24
Q

Which phase is characterized by an equlibrium between the Ab synthesis and Ab decay

A

Steady-state Phase

25
Q

biggest Ig

26
Q

refers to the number of antigenic determinants an individual Ab molecule can bind

A

Valency (normally 2)

28
Q

Active or Passive Immunity. lack of memory from the original antigen

A

Passive immunity

30
Q

Composition of Ig structure (4)

A

2 Light Chains 2 Heavy Chains *both identical

31
Q

the carboxyl terminal of which chain facilitates the effector function of Ig’s

A

Heavy chain (Fc portion)

32
Q

A region between the complementarity determining region in the variable region of the Ig

A

Framework Region

34
Q

which has more immunogenicity: 1. soluble or insoluble immunogens 2. native or denatured immunogens

A
  1. insoluble 2. denatured
34
Q

Characterixstics of T-independent Antigens

A

Polysaccharides Polymeric in structure

35
Q

which terminal of both Light chain and heavy chain participates in the An binding?

A

Amino terminal

37
Q

Which cell primarily responds to protein antigens only?

38
Q

Active or Passive Immunity. Placental transfer

A

Passive immunity

39
Q

has the property of Antigenicity but not immunigenicity (unless bound to carriers)

39
Q

Main Ig in secondary response

40
Q

Differentiate Primary and Secondary Response as to: 1. Antibody production 2. predominant Ig 3. Antigen clearance

A

Primary-Secondary 1. Slow-Fast 2. IgM-IgG 3. Slow-Fast

41
Q

sometimes referred as 11s immunoglobulin

42
Q

least common serum Ig

43
Q

type of antigens that can directly stimulate the B cells to produce Ab

A

T-independent Antigens

44
Q

Monomeric Ig molecules

A

IgG, IgD, IgE, IgA (serum)

45
Q

A substance that induces a state of sensitivity or resistance

47
Q

Ig molecules that is often associated to J-protein

49
Q

a region where most of the variablity in the Ig resides (3 regions)

A

Hypervariability Region (HVR) or Complementarity-Determining Region (CDR)

51
Q

IgG subclass that does not fix complement

52
Q

2 divisions of the functions of immunoglobulins

A

Atibody binding Effector functions

53
Q

T/F.F(ab’)2 binding to antigen still has effector functions

55
Q

Types of antigens

A

T-dependent Antigens T-independent Antigens

56
Q

Which type of An response elicits a better secondary response?

A

T-cell dependent

57
Q

Give the subtypes: 1. Light Chain 2. Heavy Chain

A
  1. Kappa and lambda 2. Gamma, Alpha, Mu, Epsilon, Delta
58
Q

First Ig produced by the fetus and the first Ig made by virgin B cells

59
Q

Identify line of defense: 1. Fever 2. Ab 3. B cells 4. Antimicrobial Substances 5. Mucus membranes 6. normal flora

A
  1. 2nd line 2. 3rd line 3. 3rd line 4. 2nd line 5. 1st line 6. 1st line
60
Q

which part of the Ig is the CHO moiety attached?

A

CH2 (second Constant region of the Heavy chain)

MICROBIOLOGY 1.0 (6 decks)

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