Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

MICROBIOLOGY 1.0 > 1.9a Humoral Immunity > Flashcards

1.9a Humoral Immunity Flashcards

You may prefer our related Brainscape-certified flashcards:
Biology 101 flashcards
1
Q

smallest unit of a complex antigen that is capable of binding to an Ab

A

epitope

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is/are the product in the ffg: 1. Papain + Ig 2. Pepsin + Ig

A
  1. 2 identical Fab regions and 1 Fc region 2. F(ab’)2 (divalent Antigen binding sites)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Ig that is primarily found on the Bcell surface

A

IgD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

an Ig that has an Fc potion already bound even before antigen binding.

A

IgE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Phases of Primary Immunogen clearance

A

Equilibrium Phase Catabolic Phase Immune elimination phase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

region in the Ig structure that offers great flexibility

A

Hinge region

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what is the immunogenic component in the hapten-carrier conjugate complex?

A

Carriers (not the hapten)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

T/F. IgD fixes complement cascade

A

False

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

relation of immunogenicity to size of immunogen

A

Direct

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what type of Antigen has no Equilibrium phase?

A

Particulate/Insoluble Antigens

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

2nd most abundant serum Ig

A

IgA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

relation of immunogenicity to chemical composition simplicity of immunogen

A

Indirect

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

which cell responds to small antigenic size of 4-8 residues only

A

B cells (T cells: 8-15 residues)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

cells that cannot recognize free peptides/antigens

A

T cells (require MHC from APC’s)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

main Ig produced early in th eprimary immune response

A

IgM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

2 effector functions of immunoglobulins

A

Complement fixation bind to various cell types

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Factors affecting the immunogenicity

A

(from immunogens) Foreignness Size Chemical Composition Physical Form Degradability (from biological System) Genectic Factor Age

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what cell facilitates Ab secretion?

A

Plasma cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Active or Passive Immunity. More Powerful.

A

Passive immunity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

When does the Antibody in the serum detected? A. After Equilibrium Phase B. Before Catabolic Phase C. During Catabolic Phase D. After Immune Elimination phase

A

D. After Immune Elimination phase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Active or Passive Immunity. Long term

A

Active immunity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

any particle that induces a specific immune response

A

Antigen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

IgG subclass that cannot pass through the placenta

A

IgG2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Which biomolecule is the best immunogens?

A

Proteins (Proteins>CHO>Nucleic acid>lipids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Active or Passive Immunity Amplification of plasma cells

A

Active immunity

21
Q

are substances that can enhance the immune response

A

Adjuvants

22
Q

type of T-independent Ag that can activate polyclonal B cells

A

Type 1

22
Q

An Ig with Alpha as heavy chain can have both kappa and Lambda as light chains

A

False if in one Ig True if different Ig

23
Q

What is the major serum Ig?

A

IgG

24
Q

Which phase is characterized by an equlibrium between the Ab synthesis and Ab decay

A

Steady-state Phase

25
Q

biggest Ig

A

IgM

26
Q

refers to the number of antigenic determinants an individual Ab molecule can bind

A

Valency (normally 2)

28
Q

Active or Passive Immunity. lack of memory from the original antigen

A

Passive immunity

30
Q

Composition of Ig structure (4)

A

2 Light Chains 2 Heavy Chains *both identical

31
Q

the carboxyl terminal of which chain facilitates the effector function of Ig’s

A

Heavy chain (Fc portion)

32
Q

A region between the complementarity determining region in the variable region of the Ig

A

Framework Region

34
Q

which has more immunogenicity: 1. soluble or insoluble immunogens 2. native or denatured immunogens

A
  1. insoluble 2. denatured
34
Q

Characterixstics of T-independent Antigens

A

Polysaccharides Polymeric in structure

35
Q

which terminal of both Light chain and heavy chain participates in the An binding?

A

Amino terminal

37
Q

Which cell primarily responds to protein antigens only?

A

T-cells

38
Q

Active or Passive Immunity. Placental transfer

A

Passive immunity

39
Q

has the property of Antigenicity but not immunigenicity (unless bound to carriers)

A

Hapten

39
Q

Main Ig in secondary response

A

IgG

40
Q

Differentiate Primary and Secondary Response as to: 1. Antibody production 2. predominant Ig 3. Antigen clearance

A

Primary-Secondary 1. Slow-Fast 2. IgM-IgG 3. Slow-Fast

41
Q

sometimes referred as 11s immunoglobulin

A

IgA

42
Q

least common serum Ig

A

IgE

43
Q

type of antigens that can directly stimulate the B cells to produce Ab

A

T-independent Antigens

44
Q

Monomeric Ig molecules

A

IgG, IgD, IgE, IgA (serum)

45
Q

A substance that induces a state of sensitivity or resistance

A

Immunogen

47
Q

Ig molecules that is often associated to J-protein

A

IgM, IgA

49
Q

a region where most of the variablity in the Ig resides (3 regions)

A

Hypervariability Region (HVR) or Complementarity-Determining Region (CDR)

51
Q

IgG subclass that does not fix complement

A

IgG4

52
Q

2 divisions of the functions of immunoglobulins

A

Atibody binding Effector functions

53
Q

T/F.F(ab’)2 binding to antigen still has effector functions

A

False

55
Q

Types of antigens

A

T-dependent Antigens T-independent Antigens

56
Q

Which type of An response elicits a better secondary response?

A

T-cell dependent

57
Q

Give the subtypes: 1. Light Chain 2. Heavy Chain

A
  1. Kappa and lambda 2. Gamma, Alpha, Mu, Epsilon, Delta
58
Q

First Ig produced by the fetus and the first Ig made by virgin B cells

A

IgM

59
Q

Identify line of defense: 1. Fever 2. Ab 3. B cells 4. Antimicrobial Substances 5. Mucus membranes 6. normal flora

A
  1. 2nd line 2. 3rd line 3. 3rd line 4. 2nd line 5. 1st line 6. 1st line
60
Q

which part of the Ig is the CHO moiety attached?

A

CH2 (second Constant region of the Heavy chain)

MICROBIOLOGY 1.0 (6 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions