#199 Use of Prophylactic Antibiotics in Labor and Delivery Flashcards
According to the CDC what % of antibiotics prescribed in acute care hospitals in the US are inappropriate?
20-50%
A comparison of very-low-birth-weight neonates (<1500g) born between 1998 and 2000 and 1991 and 1993 showed increase, decrease, or same incidence of early-onset neonatal sepsis from GBS? For Sepsis caused by e coli?
Decrease incidence of neonatal sepsis from GBS. Increase in sepsis caused by E coli.
Is sepsis in very-low-birth-weight neonates with ampicillin-resistant E coli more or less likely to be fatal than neonates with susceptible strains?
More likely to be fatal
What % of GBS isolates are resistant to erythromycin and clindamycin?
Up to 30%
What is the incidence of severe allergic reaction to penicillin? Less severe reactions?
1 in 2,500-25,000. 10% with less severe reactions
What % of patients who receive antibiotic in hospital will have severe adverse reaction?
Approximately 5%
What % of patients with a PCN allergy may react if given a cephalosporin?
Up to 10%
What is the risk of skin reactions (urticaria, rash, pruritius) and anaphylaxis to cephalosporin administration?
Skin reaction: 1-3%
Anaphylaxis: 0.001-0.1%
How does the physiologic state of pregnancy affect levels of antibiotics, how?
Increased GFR (decreases drug half-life, lower peak serum level), increased plasma volume (large volume of distribution), Hormone-mediated increases in binding proteins, decreased gastric emptying time and acidity (may change oral absorption of drugs)
What antibiotics are known to reach fetal concentrations of 30-90% of maternal serum in the 2nd trimester and beyond?
Include ampicillin, cephalothin, clindamycin, vancomycin, azithromycin, and aminoglycosides
What is the dose of cefazolin prior to cesarean section? Based on weight.
Can use standardized 2g dose.
If <80kg can do 1g.
In non ob patients can do 3g in patients 120kg or more, but not strongly supported in Ob literature.
What effect does vaginal cleansing prior to cesarean section have for women who were in labor or those with ruptured membranes.
Reduced risk of endometritis and postoperative fever, but does not decrease risk of wound infection.
What solutions can be used for vaginal preparation prior to cesarean section?
10% providone-iodine or chlorhexidine gluconate with 4% alcohol
What is the single most important risk factor for infection in the postpartum period?
Cesarean section.
What should you do if antibiotic prophylaxis was not able to be administered prior to start of cesearean section (eg stat delivery)?
Administer as soon as possible after incision is made
What is alternative antibiotic regimen for pre op antibiotics for cesarean section if someone has a significant penicillin allergy?
Single-dose combination of clindamycin (900mg) with an aminoglycoside (5mg/kg)
What does the current evidence say regarding azithromycin use for cesarean deliveries?
Supports use for women undergoing nonelective cesarean delivery
How do surgical site infection rates compare after cesarean section if patients receive ancef within 1 hour of incision vs greater than 1 hour before incision?
Double the rate of SSI if more than 1 hour before incision
When should patients in a cesarean section receive additional ancef?
If surgery >4 hours, if EBL >1500cc
Does pre operative cesarean section antibiotics change if patient is known MRSA carrier?
Can consider adding vanc to regimen (vanc is not sufficient coverage by itself for cesarean delivery ppx)
Does latency antibiotics for PPROM affect neonatal morbidity and mortality?
Reduces respiratory distress syndrome, necrotizing enterocoloitis, intraventricular hemorrhage, and early onset sepsis
Does antibiotic prophylaxis after PPROM affect maternal infectious complications?
yes, reduces them
Why is amoxicillin-clavulanic acid contraindicated for latency antibiotics for PPROM?
Increased risk of neonatal necrotizing enterocolitis
If someone is tested for GBS in the setting of PPROM and results are negative, but patient delivers 6 wks later, what do you do?
Should retest prior to delivery if 5 or more weeks since negative baseline GBS test
If someone is tested for GBS in the setting of PPROM and results are positive, but patient delivers 6 wks later, what do you do?
Test does not need to be repeated and patient should receive GBS prophylaxis
Is infective endocarditis prophylaxis recommended for women with acquired or congenital structural heart disease for either vaginal or cesarean delivery?
No, only conditions associated with the highest risk of adverse outcomes from endocarditis are appropriate for prophylaxis [cyanotic heart dx, prosthestic valves, or both]
What cardiac conditions have a high risk of endocarditis in the presence of bacteremia?
Prosthetic cardiac valve or prosthetic material used for valve repair, previous infectious endocarditis, patients with CHD [unrepaired cyanotic CHD, repaired CHD repaired with prosthetic material or device during first 6mo post op, repaired CHD with residual defects], cardiac transplant recipients with valve regurg d/t structurally abnormal valve
What antibiotics can be used for infective endocarditis antibiotic prophylaxis regimens for high-risk women?
IV: ampicillin 2g IV or ancef 2g IV or ceftriaxone 1g IV
Allergic to PCN: ancef or ceftriaxone 1g or clindamycin 900mg
Oral: amoxicillin 2g
Oral, allergic to PCN: keflex 2g, clindamycin 60mg, azithromycin 500mg
Is antibiotic prophylaxis appropriate for patients undergoing repair of 3rd degree or 4th degree lacerations?
A single dose of antibiotic at the time of repair is reasonable in the setting of OASIS
Is antibiotic prophylaxis recommended for history-, ultrasonography-, or examination-indicated cervical cerclage?
Evidence insufficient to recommend antibiotic prophylaxis
What is the risk (%) of preexisting chorioamnionitis as a cause of cervical insufficiency?
Approximately 33%. Often subclinical
Are antibiotics recommended for manual removal of the placenta after vaginal delivery?
existing data do not support antibiotic use
Are antibiotics recommended for postpartum dilation and curettage?
No data to recommend for or against prophylactic antibiotics
Are antibiotics recommended for placement of indwelling intrauterine balloon catheter in setting of retained placenta or postpartum hemorrhage?
No data to recommend for or against prophylactic antibiotics
Which patients do not need pre op antibiotic prophylaxis for cesarean section?
If already receiving an antibiotic regimen with equivalent broad-spectrum coverage (eg, for chorioamnionitis)
Should antibiotic prophylaxis be used for pregnancy prolongation in women with preterm labor and intact membranes?
No
Should all pregnant women receive MRSA screening?
No
