18.4-18.6 Cardiac Muscle Flashcards
Striated, short, branched, fat, and interconnected
Cardiac muscle cells
Cardiomyocytes
Contain numerous large mitochondria, which resist fatigue
One central nucleus
Rest of volume composed of sarcomeres
Cardiac muscle cells
Wider, but less numerous in cardiac muscle cells
T tubules
Simpler in cardiac muscle rather than in skeletal muscle
Sarcoplasmic reticulum
Connecting junctions between cardiac cells
Intercalated discs
Allow ions to pass from cell to cell
Electrically couple adjacent cells
Allows heart to be a functional syncytium
Gap junctions
Holds cell together
Prevents cells from separating
Velcrow like
Desmosomes
- Muscle contraction is preceded by depolarizing action potential
- Depolarization wave travels down T tubules
- Excitation-contraction coupling occurs
Similarities between skeletal and cardiac muscles
Cardiac muscle type; Responsible for contraction
Bulk of heart and are responsible for pumping action
Contractile cells
Cardiac muscle type; Autorhythmic cells
Non Contractile cells that spontaneously depolarize and initiate depolarization of entire heart
No nervous system support (self-excitable)
Pacemaker cells
Network of pacemaker cells; Initiate and distribute impulses to coordinate depolarization and contraction of heart
Electrical events precede mechanical events
5 parts
Intrinsic cardiac conduction system
“Pacemaker” of the heart
Sinoatrial node (SA node)
Rhythm of the SA node and determines heart rate
Sinus rhythm
Device that can detect electrical currents generated by the heart
Electrocardiograph
A graphic recording of electrical activity of the heart
EKG
Depolarization of SA node and atria
First wave
P wave
Ventricular depolarization and atrial repolarization
QRS Complex
Ventricular repolarization
T wave
Beginning of atrial excitation to beginning of ventricular excitation
P-R interval
Entire ventricular myocardium depolarized
Flat line on EKG
S-T segment
Beginning of ventricular depolarization through ventricular repolarization
Q-T interval
Depolarization and repolarization
Electrical events
Contraction of heart
Systole
Relaxation of heart
Diastole
Cardiomyocytes in an area contract as a unit
Functional syncytium
Does cardiac muscle use extracellular Ca2+?
Yes
True or false. Tetanic (sustained) contractions cannot occur in cardiac muscles
True
True or false. Cardiac muscle relies more on oxygen than skeletal muscle?
True - More mitochondria
Unstable resting membrane potential in cardiac muscle cells
Never a flat line; upward trend from trough to threshold
Na+ open, K+ close
Pacemaker potential
Pacemaker potential
Depolarization
Repolarization
Cardiac AP
Action potential begins when pacemaker potential reaches threhold; Ca2+ influx through channels
Depolarization
Ca2+ channels inactivating and K+ channels opening
K+ efflux, brining membrane potential back to original voltage
Repolarization
Where impulses pause in conduction system
Part 2
AV node
Connects atria to ventricles
AV bundle
Irregular heart rhythms
Arrhythmias
(Murmurs)
Rapid, irregular heart beat
Heart useless for pumping blood
Fibrillation
Defective AV node
AP “blocked”
Heart block
Increase rate and force of heartbeat
“Accelerator”
Fight or flight
Sympathetic nervous system
Slows heart rate down
Parasympathetic nervous system
Depolarization due to Na+ influx through fast voltage-gated Na+ channels
Depolarization of contractile muscle cells
Due to Ca2+ influx through slow Ca2+ channels
Keeps cell depolarized because K+ channels are closed
Plateau phase of contractile muscle cells
Due to Ca2+ inactivating
Repolarization of contractile muscle cells
True or false. Are action potentials and contraction longer in cardiac muscle?
True
Longer contraction ensures efficient blood ______
Ejection
First stage of cardiac cycle; 80% of blood passively flows from atria through open AV valves into ventricles
AV = open
SL = closed
Fills ventricles with blood
Ventricular filling
Second stage of cardiac cycle; Atria relax and ventricles contract; Rising ventricular pressure causes closing of AV valves
Blood flows into pulmonary trunk and aorta
AV = closed
SL = open
Ventricular systole
Following T wave; Ventricles relax and atria fill with blood
AV = open
SL = closed
Early diastole
(Isovolumetric relaxation)
Volume of blood in each ventricle at end of each ventricular diastole
End diastolic volume (EDV)
Volume of blood remaining in each ventricle after systole
End systolic volume (ESV)
cardiac cycle page