18 Virus: Immunity and Pathogenesis

Question 1

TLR receptors

Answer 1

1: Lipoprotein (Zymosan, yeast)
2: Lipoproteins, Peptidoglycan
3: dsRNA
4: LPS
5: Flagellin
6: Lipoproteins
7:ssRNA
8:ssRNA
9:CpG DNA
10:?
11: Profillin

CAN BIND VIRUSES

Question 2

RIG1
MDA5

Answer 2

RIG1 binds uncapped RNA
MDA5 binds long dsRNA

Card domain after activation exposed and interaction with MAVS to phosphorylate IRF3/7 to activate NF-kappaB and to induce proinflammatory responses

Question 3

ISGs and example

Answer 3

Interferon stimulated genes, genes that arr stimulated after receptor activation through Interferon 1/3

ISRE (Interferon stimulated response elements) and GAS (gamma act sequence)

Question 4

INterferon pathways

Answer 4

mxGTPase pathway
block viral transcription

OAS - Ribonuclease L pathway
degrade viral RNA

Protein kinase K pathway
inhibit viral translation

ISG15 - ubiquitin like pathway
modify protein function

Question 5

Virus and Bacteria where only one pathogen is enough

Answer 5

Q Fever and Measles

Question 6

West Nil virus

Answer 6

mosquito borne +ssRNA virus

USA epidemic cause it spreaded without obvoius disease but leads to severe cases in some cases