17. Breathlessness Flashcards

1
Q

Define dyspnoea

A

Difficult or laboured breathing in which the subject is conscious of being short of breath aka. breathlessness

Definition of breathlessness: undue awareness of breathing or awareness of difficulty breathing

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2
Q

What is meant by breathlessness?

A

Sensations of all or any of the below:
Awareness of breathing normally absent
A sensation of air hunger/requiring more air
Difficulty breathing in
Difficulty breathing out
Feeling that the chest is filled up
Perception of respiratory rate and gasps or sighs

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3
Q

What is the pathophysiology of breathlessness ? (Brief)

A

Three main components - afferent input, efferent output, central information processing

Central processing in dyspnoea results in mismatch between the afferent and the efferent - so the need for ventilation is not met by the physical breathing

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4
Q

What are the causes of breathlessness?

A
Hypoxia
Metabolic acidosis
Hypotension/reduced cardiac output
Breathing CO2
Exercise
Pregnancy
Anxiety
Pulmonary oedema
Anaemia
Obstruction of the pulmonary artery
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5
Q

By what mechanism does hypoxia, metabolic acidosis and hypotension cause dyspnoea/breathlessness?

A

By a low pO2/altered pH being recognised by the peripheral chemoreceptors

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6
Q

How does the function of the respiratory muscles change when there is airway obstruction?

A

When there is resistance i.e. airway obstruction, brain activity increases with increased input from the chest wall muscles and their stretch receptors

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7
Q

What are J receptors and how do they function in the lung?

A

AKA. Pulmonary C-fibre receptors
J receptors are situated next to capillaries in the bronchial wall
These are slow speed C fibres and result in vagal input to the brainstem
Activation of these receptors leads to shortened expiration and increased respiratory frequency

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8
Q

What can activate J receptors?

A

Local congestion i.e. pneumonia, pulmonary emboli, pulmonary odoema, congestive heart failure - essentially any cause leading to a reduced oxygenation of the lung

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9
Q

What does the activation of J receptors result in?

A

Activation causes a reflexive increase in breathing rate and so leads to increased rate of ventilation

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10
Q

What neurological factors can lead to breathlessness?

A
Anxiety
Depression
Temperature
Hormones
Hyperventilation
Desensitisation and acclimatisation
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11
Q

What different tests can be used to test lung function?

A
Tests of airflow and resistance
Tests of lung volume with measurement of residual volume and air trapping
Tests of gas transfer
Repeated measurements over time
Exercise testing
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12
Q

Why are transplant patients particularly prone to becoming breathless?

A

These patients have no input via the J receptors or stretch receptors and so have no mechanism to prevent the sensation of breathlessness

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13
Q

What treatments can be used for breathlessness?

A
Find the cause and treat it
(Bronchodilators and steroids
Oxygen
Morphine
Diazepam
Retraining and exercise)
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14
Q

How can exercise cause breathlessness?

A

Increases the pCO2 level
Sensed via afferents from the skeletal muscles
Stimulates the respiratory centre

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15
Q

How does pregnancy lead to breathlessness?

A

Due to direct effect on the respiratory centre due to increased levels of progesterone
Also results in an increased CO2 production

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16
Q

How does pulmonary oedema cause breathlessness?

A

Stimulation of the J receptors of the lungs

17
Q

How can patients present with breathlessness?

A
Shortness of breath
Cough
Sputum
Wheeze
Chest pain 
Palpitations
Systemic symptoms e.g. night sweats and weight loss