16 REN overview Flashcards

1
Q

What 4 sorts of pharmacology do we consider with the urinary system?

A

Diuretics
RAAN
Vaptans
lower urinary tract function

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2
Q

What does Furosemide target?

A

NKCC2

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3
Q

What absorbs sodium in the DCT and collecting duct?

A

ENaC

epithelial sodium channel

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4
Q

what does amiloride do, what is it used as?

A

inhibits ENaC

antihypertensive

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5
Q

What substances might have a renal clearance higher than the GFR?

A

reabsorbed substances

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6
Q

What substances might have a renal clearance lower than the GFR?

A

actively secreted substances

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7
Q

What is the RAAS activated?

A

HTN

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8
Q

What 4 drug types can we use to inhibit the RAAS?

A

ACEi
AT1 receptor antagonists
aldosterone receptor antagonist
renin inhibition

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9
Q

What suffix is used for ACEi?

A

-opril

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10
Q

What suffix is used for AT1 receptor antagonists?

A

-sartans (ARB)

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11
Q

name an aldosterone receptor antagonist

A

sprinolactone

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12
Q

Name a renin inhibitor

A

aliskiren

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13
Q

Can people survive without autonomic innervation to the kidney?

what does this suggest?

A

yes

SNS regulation of renin isn’t all that important

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14
Q

What is the highest drive for ADH regulation?

A

osmolality

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15
Q

what is the most important urinary pH buffer?

A

phosphate

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16
Q

Where might we put a donated kidney?

A

iliac fossa

17
Q

What is the state of the nervous systems in urinary continence?

A

somatic + sympathetic active

parasympathetic inactive

18
Q

What is the sate of the nervous systems in voiding?

A

somatic + sympathetic inactive

parasympathetic active

19
Q

What is the role of the PNS in voiding?

A

contraction of storage elements in the walls

20
Q

What is the role of the somatic NS in continence?

A

keeps striated sphincter contracted

21
Q

What is the role of the sympathetic NS in continence

A

constricts smooth muscle sphincters

keeps storage element released

22
Q

What is the process of urodynamics?

A
pelvic floor relaxes
urethral pressure decreases
rise in bladder pressure
pressure gradient established
urine passes