16 REN overview Flashcards
What 4 sorts of pharmacology do we consider with the urinary system?
Diuretics
RAAN
Vaptans
lower urinary tract function
What does Furosemide target?
NKCC2
What absorbs sodium in the DCT and collecting duct?
ENaC
epithelial sodium channel
what does amiloride do, what is it used as?
inhibits ENaC
antihypertensive
What substances might have a renal clearance higher than the GFR?
reabsorbed substances
What substances might have a renal clearance lower than the GFR?
actively secreted substances
What is the RAAS activated?
HTN
What 4 drug types can we use to inhibit the RAAS?
ACEi
AT1 receptor antagonists
aldosterone receptor antagonist
renin inhibition
What suffix is used for ACEi?
-opril
What suffix is used for AT1 receptor antagonists?
-sartans (ARB)
name an aldosterone receptor antagonist
sprinolactone
Name a renin inhibitor
aliskiren
Can people survive without autonomic innervation to the kidney?
what does this suggest?
yes
SNS regulation of renin isn’t all that important
What is the highest drive for ADH regulation?
osmolality
what is the most important urinary pH buffer?
phosphate