Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

CNS > 16. Drugs for Depression and Anxiety > Flashcards

16. Drugs for Depression and Anxiety Flashcards

1
Q

What are the core symptoms of depression?

A

Depressed mood
Anhedonia
Lack of energy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the treatment options for depression?

A

Mild: CBT
Moderate to severe: pharmacological
Severe resistant: electroconvulsant therapy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Name 2 tricyclic antidepressants

A

Imipramine

Amitriptyline

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the MOA of tricyclic antidepressants?

A

Stop serotonin and NA reuptake

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are the side effects of tricyclic antidepressants?

A

H1 receptors: drowsiness and sedation
a1 adrenergic: postural hypotension, dizziness
Muscarinic: dry mouth, blurred vision, memory impairment
Narrow therapeutic range

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Name 2 SSRIs

A

Fluoxetine

Sertraline

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is the MOA of SSRIs?

A

Selectively block serotonin uptake

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are the side effects of SSRIs?

A

nausea, bleeding
Headache, anxiety, insomnia, sexual dysfunction
Hyponatraemia
Serotonin syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

When are serotonin norepinephrine reuptake inhibitors used?

A

SSRIs don’t work

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Name 3 SNRIs

A

Venlafaxine
Desvenlafaxine
Duloxetine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are the side effects of SNRIs?

A

Nausea

Dose-related hypertension

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

When are monoamine oxidase inhibitors used?

A

Rarely as lethal interactions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are the side effects of monoamine oxidase inhibitors?

A

With tyramine causes intracranial haemorrhage

Headache, hypotension

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are the active compounds in St John’s Wort?

A

Hyperforin and adhyperforin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the first line treatment for generalised anxiety disorders?

A

SSRI such as sertaline

2-3 week lag before working so co-prescribe short term benzodiazepine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Name a tricyclic antidepressant useful in obsession and phobia

A

Clomipramine

17
Q

What anxiety disorders are MAO-Is useful in?

A

Resistant morbid anxiety

Panic attacks

18
Q

What is the treatment for anxiety that is not improved after sertaline for 2 months?

A

Increase dose or switch to alternative SSRI or SNRI

19
Q

What are the side effects of benzodiazepines?

A

Withdrawal and dependence
Enhance depressant effects of alcohol
Resp insufficiency with underlying conditions

20
Q

Name 2 benzodiazepines that can be used as hypnotics for sleep disturbance

A

Nitrazapam

Flurazepam

21
Q

What drugs should be used in the short term vs long term treatment of sleep disturbance?

A

Short: hypnotics
Chronic: TCAs

22
Q

Name 3 classes of non-benzodiazepine hypnotics

A

Z-drugs
Anti-histamines
Melatonin

23
Q

What are the uses of b-blockers in anxiety?

A

Used for physical symptoms eg. tremor, sweating, shortness of breath

24
Q

What is the MOA of buspirone?

A

Partial agonist at 5-HT1

25
Q

What anti-convulsants are useful in anxiety?

A

Pregabalin

Sodium valproate

CNS (21 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions