15 Bordetella, Haemophilus, Moraxella Flashcards
what anatomical location are bordetella, haemophilus, and moraxells typically found?
upper airway
bordetella grows on what agar? Has what shape?
-bordet-gengou or regan-lowe-coccobacillus
T/F B. pertussis is aerobic? Non-fastidious?
-T-F
what is infection rate of whooping cough?
100% in unvaccinated (but may not show symptoms)
what 2 organisms cause whooping cough?
B. pertussis, parapertussis
pertussis is common in what age group?
less than 5 yrs
when did vaccination start for pertussis? before that, what was mortality rate?
1940’s1%
T/F recently there is an increase in pertussis?
T (non-vaccinaters)
T/F pertussis vaccination is world-wide?
F
Catarrhal stage pertussis how many weeks?
1-2 wks
paroxysmal stage pertussis how many weeks?
2-8
convalescent stage pertussis is what?
symptoms get better (after paroxysmal stage)
Which pertussis stage is most contagious?
catarrhal
List B. pertussis MAIN virulence factors? (3)
-filamentous hemagglutinin (adhere to glycolipids in CILIATED epithelium)-pertussis toxin (also an adhesion)-pertactin (adhere to cells)
what type of toxin is pertussis toxin? What’s its mechanism?
-A-B toxin, ADP-ribosylating-up Gs ->up adenylate cyclase ->up cAMP -> ions are expelled from cell ->paralyzes cell (up respiratory mucus)
List B. pertussis additional toxins? (4)
-cya toxin (anti-inflamm, anti-phagocytic)-dermonecrotic toxin-tracheal toxin (cilia paralysis)-endotoxin
pneumonia, otitis media, seizures, encephalopathy, death are complications of what disease?
pertussis [of these pneumonia is the MOST common. death is rare.]
What symptoms when a vaccinated individual gets pertussis?
90-day cough can be only symptom, or sometimes also scratchy throat, episodes of sweating, post-tussive vomiting