14 Study Guide Flashcards
1
Q
Which compounds have dipole dipole reactions?
A
Alcohol, Ketone, etc.
2
Q
Which compounds have dipole dipole reactions?
A
Alcohol, Ketone, etc.
3
Q
What are some common infusion related ADRs of IVIG?
A
HA and Arthralgia as well as possible renal toxicity
4
Q
What would be a better choice between Morphine CR and Hydromorphone in a patient that requires acute pain control?
A
Hydromorphone b/c it has quicker onset relative to controlled release
5
Q
Iron has the best absorption with?
A
Ascorbic acid
6
Q
What do you take for iron toxicity?
A
Deferoxamine
7
Q
What is the DDI with Sulfa and Omeprazole?
A
No DDI with these two agents
8
Q
What are the targeted Phenytoin Levels?
A
10-20mcg/L
9
Q
What factors are derived from plasma?
A
Plasma, IVIG, Alpha-something ase, Factor IX
10
Q
Which benzos have no CYP metabolism?
A
LOT: Lorazepam, Oxazepam, Temazepam. Glucuronidation only, good for elderly
11
Q
Which statins have the most CYP?
A
SAL: Simvastatin, Atorvastatin, Lovastatin
12
Q
Which statins have the fewest CYP interaction?
A
Pravastatin, Rosuvastatin, Fluvastatin
13
Q
Which analgesic requires CYP for activation?
A
Codeine (2D6 to morphine)
14
Q
Where would you look up a generic name that your pharmacy doesn’t have?
A
Red Book
15
Q
Which drug indicates that a patient needs pneumococcal vaccine?
A
Digoxin
16
Q
What medication for constipation is most low acting?
A
Psyllium
17
Q
What do you give for gout attack?
A
NSAID first line
18
Q
What is a serious ADR of Xolair?
A
Anaphylaxis
19
Q
What should be remembered about Medrol dose pack?
A
Take with food and may cause insomnia
20
Q
What are some short acting steroids?
A
Hydrocortisone/Cortisone
21
Q
What are some intermediate acting steroids?
A
Methylprednisone, Prenisolone, Prednisone
22
Q
What are some long acting steroids?
A
Beta/dexamethasone
23
Q
What is the correct dose for prednisone for acute asthma exacerbation?
A
40mg daily for 6 days
24
Q
What is a DM medication that is used to decrease post-prandial glucose?
A
Sulfonylureas, Meglitinides
25
What can an alcoholic take that could potentially protect her liver?
Milk thistle
26
When is a patient with COPD a candidate for empiric Abx treatment?
Increased sputum purulence, Increased sputum volume, Dyspnea
27
What is TACE as it relates to TNF and IL-1?
Binding to soluble TNF
28
An 8 year old boy is prescribed prednisone 20mg PO QD #100. What would you counsel his parent about?
Don't d/c w/o consulting MD first. This medication can cause growth suppression
29
Which BBs are approved for CHF?
Coreg and Metoprolol Succinate
30
What is normal Prothrombin Time?
10-13 seconds
31
What is the time window to use antiplatelet drugs for stroke?
3 hours (up to 4.5h for certain circumstances)
32
What are the different LDL goals, considering CVD?
< 100 if no over CVD. < 70 if overt CVD
33
If you're trying to target TGs for a patient before anything else, what are the best agents to use?
Fibrates! Niacin is a second line agent
34
What factors can decrease INR?
St. Johns Wort. CoQ10. Ginseng. Green tea
35
What factors can increase INR?
Fish oil. Garlic. Ginger. Gingko. Vitamin E
36
What are the GPIIb/IIIa inhibitors?
TEA: Tirofiban. Eptifibitide. Abciximab
37
Patient needs a diuretic but has had SJS in the past, what would you give?
Ethacrynic acid
38
When are ACE-I/ARBs CI?
3rd trimester pregnancy
39
Patient needs HTN med that increases K level?
Spironolactone
40
CCB that decreases HR?
Verapamil and Diltiazem
41
What are the effects of Hypothyroidism on coumadin?
Hypothyroidism will cause a delayed response to coumadin d/t the slow metabolism of clotting factors by the liver
42
Zometa (Zolindronic acid) for osteoporosis, whats the dose?
5mg IV Q yearly
43
How would you know if patient has Folic Acid deficiency anemia?
High MCV. B12 is normal
44
Which DM medications have BBWs?
Metformin (lactic acidosis). Pioglitazone (cause or exacebate CHF)
45
What what A1c do you initiate dual therapy?
7.5-9
46
Physician orders a 10U IV bolus, what type of insulin do you give?
Only R insulin can be given as bolus
47
Which insulin is most like endogenous insulin?
Glargine or Lantus
48
What are the birth control pills starting/back up requirements?
Sunday start: back up for 7 days. Start on first day of bleeding, no backup necessary
49
What is used for HPA axis suppression?
Prednisone daily for long term
50
What can be used OTC for menopause?
Black cohosh
51
A patient has adrenal insufficiency d/t a tumor, what should be given?
Testosterone. Aldosterone
52
What is best to decrease postprandial glucose level?
Forgot to type it in... Whoops
53
Antibiotic coverage for atypical microbes?
Doxycycline and Clarithromycin
54
Patient with foot debridement, Abx?
Cefotetan
55
Other than Strep pneumo, what organism causes CAP in otherwise healthy individuals?
Mycoplasma
56
What drugs cause urine discoloration?
Phynazopyridine. Nitrofurantoin. Rifampin
57
Which drug for overactive bladder is available in a patch?
Oxybutynin
58
Elderly needs antihistamine for sleep, what would you give?
Loratidine
59
What are some common infusion related ADRs of IVIG?
HA and Arthralgia as well as possible renal toxicity
60
What would be a better choice between Morphine CR and Hydromorphone in a patient that requires acute pain control?
Hydromorphone b/c it has quicker onset relative to controlled release
61
Iron has the best absorption with?
Ascorbic acid
62
What do you take for iron toxicity?
Deferoxamine
63
What is the DDI with Sulfa and Omeprazole?
No DDI with these two agents
64
What are the targeted Phenytoin Levels?
10-20mcg/L
65
What factors are derived from plasma?
Plasma, IVIG, Alpha-something ase, Factor IX
66
Which benzos have no CYP metabolism?
LOT: Lorazepam, Oxazepam, Temazepam. Glucuronidation only, good for elderly
67
Which statins have the most CYP?
SAL: Simvastatin, Atorvastatin, Lovastatin
68
Which statins have the fewest CYP interaction?
Pravastatin, Rosuvastatin, Fluvastatin
69
Which analgesic requires CYP for activation?
Codeine (2D6 to morphine)
70
Where would you look up a generic name that your pharmacy doesn't have?
Red Book
71
Which drug indicates that a patient needs pneumococcal vaccine?
Digoxin
72
What medication for constipation is most low acting?
Psyllium
73
What do you give for gout attack?
NSAID first line
74
What is a serious ADR of Xolair?
Anaphylaxis
75
What should be remembered about Medrol dose pack?
Take with food and may cause insomnia
76
What are some short acting steroids?
Hydrocortisone/Cortisone
77
What are some intermediate acting steroids?
Methylprednisone, Prenisolone, Prednisone
78
What are some long acting steroids?
Beta/dexamethasone
79
What is the correct dose for prednisone for acute asthma exacerbation?
40mg daily for 6 days
80
What is a DM medication that is used to decrease post-prandial glucose?
Sulfonylureas, Meglitinides
81
What can an alcoholic take that could potentially protect her liver?
Milk thistle
82
When is a patient with COPD a candidate for empiric Abx treatment?
Increased sputum purulence, Increased sputum volume, Dyspnea
83
What is TACE as it relates to TNF and IL-1?
Binding to soluble TNF
84
An 8 year old boy is prescribed prednisone 20mg PO QD #100. What would you counsel his parent about?
Don't d/c w/o consulting MD first. This medication can cause growth suppression
85
Which BBs are approved for CHF?
Coreg and Metoprolol Succinate
86
What is normal Prothrombin Time?
10-13 seconds
87
What is the time window to use antiplatelet drugs for stroke?
3 hours (up to 4.5h for certain circumstances)
88
What are the different LDL goals, considering CVD?
< 100 if no over CVD. < 70 if overt CVD
89
If you're trying to target TGs for a patient before anything else, what are the best agents to use?
Fibrates! Niacin is a second line agent
90
What factors can decrease INR?
St. Johns Wort. CoQ10. Ginseng. Green tea
91
What factors can increase INR?
Fish oil. Garlic. Ginger. Gingko. Vitamin E
92
What are the GPIIb/IIIa inhibitors?
TEA: Tirofiban. Eptifibitide. Abciximab
93
Patient needs a diuretic but has had SJS in the past, what would you give?
Ethacrynic acid
94
When are ACE-I/ARBs CI?
3rd trimester pregnancy
95
Patient needs HTN med that increases K level?
Spironolactone
96
CCB that decreases HR?
Verapamil and Diltiazem
97
What are the effects of Hypothyroidism on coumadin?
Hypothyroidism will cause a delayed response to coumadin d/t the slow metabolism of clotting factors by the liver
98
Zometa (Zolindronic acid) for osteoporosis, whats the dose?
5mg IV Q yearly
99
How would you know if patient has Folic Acid deficiency anemia?
High MCV. B12 is normal
100
Which DM medications have BBWs?
Metformin (lactic acidosis). Pioglitazone (cause or exacebate CHF)
101
What what A1c do you initiate dual therapy?
7.5-9
102
Physician orders a 10U IV bolus, what type of insulin do you give?
Only R insulin can be given as bolus
103
Which insulin is most like endogenous insulin?
Glargine or Lantus
104
What are the birth control pills starting/back up requirements?
Sunday start: back up for 7 days. Start on first day of bleeding, no backup necessary
105
What is used for HPA axis suppression?
Prednisone daily for long term
106
What can be used OTC for menopause?
Black cohosh
107
A patient has adrenal insufficiency d/t a tumor, what should be given?
Testosterone. Aldosterone
108
What is best to decrease postprandial glucose level?
Forgot to type it in... Whoops
109
Antibiotic coverage for atypical microbes?
Doxycycline and Clarithromycin
110
Patient with foot debridement, Abx?
Cefotetan
111
Other than Strep pneumo, what organism causes CAP in otherwise healthy individuals?
Mycoplasma
112
What drugs cause urine discoloration?
Phynazopyridine. Nitrofurantoin. Rifampin
113
Which drug for overactive bladder is available in a patch?
Oxybutynin
114
Elderly needs antihistamine for sleep, what would you give?
Loratidine
