02 PK Test Questions

Question 1

What is the therapeutic range for Digoxin?

Answer 1

CHF: 0.5-0.9 mgc/L. AF: 0.5-2 mcg/L

Question 2

What is the bioavailability like for Digoxin?

Answer 2

Tab (0.7), Elixir (0.8), Caps (1)

Question 3

What is the half-life of Digoxin?

Answer 3

2 days

Question 4

What is protein binding like with Digoxin?

Answer 4

Very little, 90% unbound

Question 5

What is the therapeutic range for one daily AMG dosing?

Answer 5

Peak: 20-30mg/L, Trough: undetectable

Question 6

What is the therapeutic range for conventional AMG dosing?

Answer 6

Peak: 5-8, Trough: < 2mg/L

Question 7

What is the therapeutic range for Vanco?

Answer 7

Target trough: 5-20 (4-5x MIC). Concentration INDEPENDENT bactericidal activity

Question 8

When is a loading dose usually required?

Answer 8

If the LD is 10% greater than the MD

Question 9

What should be monitored while on AMG or Vanco?

Answer 9

Obtain BUN/Scr 2-3 times weekly. Obtain CBC weekly

Question 10

How can AMGs doses be rounded?

Answer 10

To the nearest 20

Question 11

How can Vanco doses be rounded?

Answer 11

Usually in increments of 250mg for practicality

Question 12

What is the therapeutic range for Phenytoin?

Answer 12

10-20mg/L

Question 13

What is the ABW formula?

Answer 13

IBW + 0.4(TBW-IBW)

Question 14

What is the therapeutic plasma concentration for Carbamazepine?

Answer 14

4-12mg/L

Question 15

What is a quick formula to figure out the loading dose for Digoxin?

Answer 15

(Cp(V))/F