13 Death Dt Natural Causes Flashcards

1
Q

Causes of sudden and unexpected death

A
  • always in CVS
  • cerebral haemorrhage dt MVA
  • subarachnoid haemorrhage dt ruptured berrry aneurysm
  • ruptured ectopic pregnancy
  • haemoptysis dt PTB
  • haematemesis dt rultured esophageal varices
  • PE
  • ruptured aortic aneurysm
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2
Q

Cx in coronary atheroma

A
  • ulcerated plaques
  • haemorrhage within the plaques
  • coronary thrombus
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3
Q

Most common sites of coronary stenosis and occlusion

A
  • L ant descending coronary artery
  • R coronary artery
  • L circumflex artery

**almost all infarcts are in left ventricle

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4
Q

Causes of MI

A
  • coronary atheroma
  • polyartheritis of coronary
  • coronary embolism
  • ostial occlusion by syphilis
  • aortic stenosis
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5
Q

Process of early MI

A
  • oedema and pallor muscle (hours)
  • tigroid appearance/yellow and haemorrhagic areas (days)
  • myomalacia cordis leading to ruptured infarct (days to weeks)
  • gelatinous and greyish (weeks)
  • myocardial fibrosis (months)
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6
Q

Cx of MI

A
  • ruptured heart leading to haemopericardium and cardiac temponade
  • mural thrombus in L ventricle
  • pericarditis
  • myocardial fibrosis in L ventricle (septum and posterior)
  • cardiac aneurysm in L ventricle (lateral)
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7
Q

Mechanism of CAD

A
  • myocardial hypoxia leads to AF and Ventricular fibrillation and cardiac arrest and death
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8
Q

How hypertensive heart disease cause MI

A
  • concentric hypertrophy of L ventricle
  • insufficient supply of blood
  • causing MI

500-700g

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9
Q

Aortic valve ds
- which type occur in elderly and how it occurs

A
  • calcific aortic stenosis usually in elderly
  • valve thickened and rigid, fusion of valvular commissures and vegetation on cusps
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10
Q

What is cardiomyopathy and most commonly occur in which age

A

Absence of HTN or valvular ds

Usually in young adults

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11
Q

Types of cardiomyopathies

A
  • congestive
  • hypertrophic (interventricular septum)
  • obliterative
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12
Q

Histology of hypertrophic CM

A
  • irregular and large fibres
  • nuclear pleomorphism
  • criss cross muscle fibres
  • interstitial fibrosis
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13
Q

Cause and histology of myocarditis

A
  • unknown aetiology
  • 100 or more inflammatory infiltrates with myocyte necrosis
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14
Q

Definition Senile myocardium
Findings
Histology

A
  • myocardial degeneration due to senility
  • findings: heart is brown and flabby soft. The coronary vessels are torturous

Histology: lipofuscin pigments in nuclei, diffuse fibrosis of myocardium

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15
Q

Types of ruptured aortic aneurysm and patho

A
  • atheromatous aneurysm: media destruction dt fibrolipid degeneration
  • dissecting aneurysm: dt degeneration of aortic media (medianecrosis)
  • syphilitic aneurysm
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16
Q

Cause of cerebral bleeding in children

A
  • angioma
  • AV anastomosis
17
Q

Common sites of cerebral bleeding in children

A
  • bifurcation of middle cerebral artery and post comm artery
  • bifurcation of basilar arteries
  • middle cerebral artery
  • ant comm artery
18
Q

Predisposing fx of pulm thromboembolism

A
  • trauma
  • surgery
  • bed ridden
  • immobility
19
Q

Findings of epilepsy

A
  • tongue bite marks, patchy myocardial fibrosis
20
Q

How bronchial asthma cause death and findings

A
  • dt overuse of inhalers causing hypoxia and respiratory acidosis.
  • causing ventricular fibrillation dt theophylline and sympathomimetics

Findings: lung expanded, pale spongy lung, thick clear mucus in bronchus

21
Q

Causes of respiratory obstruction

A
  • rupture of retropharyngeal abscess (‘quincy’)
  • laryngeal obstruction in diphteria
  • laryngeal oedema from epiglottis (children)
22
Q

Causes and mechanism haemoptysis

A

Causes
- dt pulm tuberculosis and bronchial tumours (eroding large vessels)

Mechanism
- causing asphyxia or vagal inhibition (sudden flooding of larynx)

23
Q

Causes of GI haemorrhage

A
  • esophageal carcinoma
  • ruptured esophageal varices
  • gastric ulcer and peptic ulcer
  • carcinoma of stomach
24
Q

Causes of intestinal haemorrhage

A
  • haemorrhagic diathesis
  • colonic ca
  • ulcerative colitis
  • colonic polyp
25
Q

Causes of abdominal catastrophes

A
  • mesentric thrombosis and infarction
  • strangulated intestine
  • hernia (femoral and inguinal)
26
Q

Patho of PE, when is it occur

A

Virchows triad
- slowing of circulation (stasis)
- local injury to vessel wall (endothelial injury)
- increase blood coagulability (hypercoagulability)

Occur 2 weeks after trauma, range from 2-90 days