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Block 6 > 12.3 Alzheimer's Disease > Flashcards

12.3 Alzheimer's Disease Flashcards

1
Q

What are the plaques in AD?

A

Beta amyloid

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2
Q

What are the neurofibrillary tangles in AD?

A

Tau protein

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3
Q

What is the usual progression of AD?

A

Limbic system first affected
Frontal and temporal lobes
Visual and somatosensory spared

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4
Q

What are the three hypothesis of AD?

A

Amyloid hypothesis
Vascular hypothesis
MAM hypothesis

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5
Q

What is the amyloid hypothesis of AD?

A

Abnormal APP cleavage - AB deposition - senile plaques - neurodegeneration - AD

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6
Q

What is the vascular hypothesis of AD?

A

Advanced ageing and vascular risk factors - brain hypoperfusion - neuroglial energy crisis - mild cognitive impairment - neurodegeneration - AD

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7
Q

What is the MAM hypothesis of AD?

A

Altered lipid raft formation - altered Ca homeostasis - altered APP/tau processing - plaques/tangles/lipid droplets - neurodegeneration - AD

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