Anti Fungal Drugs Flashcards
Drugs for subcutaneous
Amphotericin B, Flucytosin, Fluconazole, Ketoconazole, Capsofungin…Variconazole
Drugs for cutaneous
Clotrimazole, Nystatin, Griseofulvin, Terbinafine,
Component in fungal cell membrane
Ergosterol
Amphotericin B is produced in
Streptomyces Nodosus…
Pharmacokinetics of Amphotericin B
Expensive Therapy
What is sodium ole-oxy cholate used for
Co formulation with Amphotericin B because it is insoluble in lipids
Class of Amphotericin B
Polyene
MOA of Amphotericin B
Binds with ergosterol in cell membrane - hydrophobic interaction - increase in permeability
Other use of Amphotericin B
Protozoal infections
Spectrum of Amphotericin B
Candida Albicans ..
Histoplasma Capsulatum…
Crytococcus neoformans.
Coccidioidomycosis
Blastomyces Dermitidis,
Aspergillus species
Most common ADRs of Amphotericin B
Thrombophlebitis
Hypotension
Hyperkalemia
Fever
Chills
What is Flucytosin
Semi synthetic anti metabolite which stops DNA synthesis
Pharmacokinetics of Flucytosin
Normal… IV and ORAL
Mechanism of Action
Goal - block the conversion of dUMP - dTMP
Spectrum of Flucytosin
Combination With Fluconazole
Combination with Amphotericin B
Chromoblastomycosis
Systematic infections and meningitis
