Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

pharmacology > DNA Gyrase Inhibitors > Flashcards

DNA Gyrase Inhibitors Flashcards

1
Q

Biggest draw back of flouroquinolone

A

Clostridium difficile infection
Bacterial resistance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Eg of flouroquinolone resistance

A

Methicillin resistance in staphylococcus aureus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Normal absorption of flouroquinolones.

A

Norfloxacine - 35-70%
Other - 80-90%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Products which reduces the abs. Of flouroquinolones

A

Dairy, Mg and Al antacids, Ca and other divalent ions…

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Safe drug in renal compro. Patient

A

Moxi-floxacin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

MOA of flouroquinolones

A

Topoisomerase 2 and 4 inhibition
Inhibition of 2… Relaxation of SUPER COILED DNA….. Inhibition of DNA breakage…

Inhibition of 4 effect chromosomal stability and inhibition of DNA replication

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Flouroquinolones spectrum

A

E.coli, haemophillus influenza pseudomonas aeruginosa
Legionella species
Clamidial species

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Respiratory flouroquinolones

A

Levo floxacin and maxi floxacin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Example of 1st gen flouroquinolones

A

Nali dixic acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Use of 1st gen flouroquinolones

A

Urithriris
Prostatitis
Infectious diarrhea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Eg of 2nd gen flouroquinolones

A

Ciprofloxacin, norfloxacine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Use of 2nd gen flouroquinolones

A

GIT , Cystis fibrosis in children, TB, Diarrhea, fever , against gram negative

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Eg of 3rd gen flouroquinolones

A

Levo floxacin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Use of 3rd gen flouroquinolones

A

Against gram +, Skin infections, community acquired infections

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Eg of 4th gen flouroquinolones

A

Moxi floxacin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Use of 4th gen flouroquinolones

A

Against gram+..
Against anaerobes such as bacteroids fragillis species..

17
Q

Common ADRs of Flouroquinolones

A

…… Phototoxicity , Hypo , hyper glycaemia,

18
Q

1 Contra. Of flouroquinolones

A

Can cause convulsions so carefully used in epileptic patient..

19
Q

Most significant ADRs of Ciprofloxacin

A

Articular cartilage errosion. So shouldn’t be given to pregnant women and children

20
Q

Biggest SE of Moxi-floxacin

A

Prolongation of QT phase so should be avoided in patients with heart condition…

21
Q

Resistance of Flouroquinolones

A

Alteration of target site, Decrease accumulation

pharmacology (11 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions