12. Tumor Immunology Flashcards
give evidence (4) that immune system responds agaisnt tumor cells give mouse experimental example.
what are the 4 ways tumor cells express antigens/
HOW do tumor stimulate CTL response?
what is cross presentation?
what example was given for MHC loss in tumor cells
how does the immune system overcome this
discuss other ways tumors evade immune system.
strategy to overcome? (4)
what are the specific inhibitory receptors?
what are the 3 phases of immune surveleince of tumors.
difference between active and passive immunity?
what about active immunity enhanced by blockade of T cell inhibitoyr molecules?
what drug has proven successful?
what about vaccine mechanism?
which 2 have been developed?
what are issues with antibody directed tumor therapy?
what is the mecahnism of action for magic bullets?
what are ways to improve these treatements?
review nomenclature of antibodies:
umab,zumab,ximab,omab
what is <!--StartFragment-->Ipilimumab <!--EndFragment-->
what cell makers (2) have been used as tumor marker for what tyype of cancers?
cancer vaccines:
traditional
recombinant
cytokine
HSP
gnetic modification
DC based
how do you Generating anti-tumor T cells of desired specificity:
