12 - immune-mediated arthritis

Question 1

initial site of pathology is synovium (unlike OA where it is articular cartilage)

Question 2

(nonerosive forms)

1. characterized by deposition of what?

Answer 2

1. antigen-antibody deposition in the synovium (type III hypersensitivity) -> stimulate inflammatory mediator release -> metalloproteinases -> cartilage degen

Question 3

(erosive forms)

1. what is an erosive form?

Answer 3

1. rheumatoid arthritis (IgG becomes antigenic - rheumatoid factor is formed in response)

Question 4

Question 5

what are the four types of non-erosive arthritis (by cause)

Answer 5

1. idiopathic (50%)
2. remote infection (25%)
3. chronic GI dz (15%)
4. remote neoplasia (10%)

Question 6

(rheumatoid arthritis)

1. most common canine erosive arthritis but less common than non-erosive
2. affects what size dogs?

Answer 6

2. smaller breed dogs of any age

Question 7

(diagnosis)

1. perform px - may see splenomegaly and lymphadenopathy
2. what % of dogs with nonerosive form have dermatitis or focal alopecia?

Answer 7

2. 30%

Question 8

(joint fluid analysis)

predominant cell type is what?

Answer 8

NON-DEGENERATVE NEURTORPHIL

Question 9

(tx)

1. non-erosive forms treated with what?
2. erosive forms?
3. sx not used for treatment

Answer 9

1. NSAIDs or corticosteroids (but not both)
2. immunosuppression with cyclophosphamide along with prednisone

Question 10

(prog)

1. good for non-erosive 1-3, bad for 4 (neoplasia)
2. erosive form?

Answer 10

2. hard to treat and really expensive!!! so not great i guess