12. CNS Stimulants

Question 1

Stimulants block presynaptic reuptake, interfere with VMAT, increase NT release (NE/DA/5HT). They enhance NT transmission by serving as direct and indirect non catecholamine sympathomimetics

Answer 1

FYI

Question 2

SE of stimulants include N/V, abdominal pain, headache, decrease appetite, weight loss, reduced growth progression in teens, insomnia, anxiety, jitteriness, irritability, aggression, agitation, psychoses, mania and elevated?

Answer 2

BP/HR

Question 3

Rare side effects of stimulants include priapism, seizures, sudden cardiac death (rare), stroke and MI, and chemical leukoderma which is basically a?

Answer 3

dry patch (daytrana patch)

Question 4

Caution using stimulants with axiety/agitation, CV disease, moderate to severe HTN, glaucoma, tourettes, bipolar, psychoses, poorly controlled seizures and with a history of?

Answer 4

drug abuse

Question 5

Stimulants are controlled substances only allowing 1 month supply, no refills, no samples and onset of activity usually is what in most patients?

Answer 5

24 hours

Question 6

All of the following are what kind of amphetamine based stimulants?
Dextroamphetamine/AMP/Adderall
Dextroamphetamine Sulfate/ ProCentra
Amphetamine Sulfate / Evekeo
Dextramphetamine/ Zenzidi

Answer 6

Immediate release amphetamine based stimulants

Question 7

What Immediate release amphetamine based stimulants comes in liquid form?

Answer 7

Dextroamphetamine Sulfate/ ProCentra

Question 8

What Immediate release amphetamine based stimulants comes in tablet form? (2)

Answer 8

Dextroamphetamine/AMP/Adderall

Dextramphetamine/ Zenzidi

Question 9

What Immediate release amphetamine based stimulants comes in capsule form? (1)

Answer 9

Amphetamine Sulfate / Evekeo

Question 10

All of the following are what kind of amphetamine base stimulants?
Dextroamphetamine/ Adderall XR
Dextroamphetamine/Dexedrine
Amphetamine/ Dyanavel XR***
Lisdexamfetamine/Vyvanse
Amphetamine (mixed salts)/ Mydayis

Answer 10

Extended Release Amphetamine-based Stimulants

Question 11

Which Extended Release Amphetamine-based Stimulants comes in liquid form? (NOTE ALL OTHERS ARE CAPSULE)

Answer 11

Amphetamine/Dyanavel XR**

Question 12

What is a form of amphetamine, and XR-oral disintegration tablet, with 50% IR and 50% XR, no water is necessary and approved for ages 6+ with QD dosing?

Answer 12

Adzenys

Question 13

All of the following are what kind of Methylphenidate-based Stimulants?
Dexmethyphenidate/Focalin
methyphenidate/ methylin
methyphenidate/ Ritalin

Answer 13

Immediate release methyphenidate based stimulants

Question 14

Which Immediated release methyphenidate based stimulants is the only one that is liquid formulation, all the rest are tablet?

Answer 14

Methyphenidate/Methylin Oral Solution

Question 15

All of the following are what kind of Methylphenidate-based Stimulants?
Methylphenidate/Ritalin SR
Methylphenidate/Desoxyn

Answer 15

Sustained release Methylphenidate based stimulant

both tablet formation

Question 16

What is an extended release Methylphenidate based stimulant that is the only one given via transdermal patch?

Answer 16

Methylphenidate Transdermal/ Daytrana

Question 17

What is an extended release Methylphenidate based stimulant that is the only one given via chewable tablet?

Answer 17

Methylphenidate HCL/ QuilliChew

Question 18

What is an extended release Methylphenidate based stimulant that is the only one given via liquid formulation?

Answer 18

Methylphenidate/ Quillivant XR

Question 19

Main MOA for non-stimulants is to enhance NT transmission via inhibition of NE pre-synaptic reuptake (atomoxetine) or agonists of CNS a2a adrenergic receptors which include guanfacine and?

Answer 19

Clonidine

Question 20

Non-stimulants have an onset of activity of 1-4 weeks*, use for patients intolerant to stimulant effects, they are non-scheduled, refills and samples are allowed and up to how many refills?

Answer 20

1 year of refills

Question 21

What is a nonstimulant medication, lasts for 24 hours, capsule form, same SE, do NOT open capsul (ocular irritant) and is metabolized by CYP2D6, approved for 6+ and has QD dosing?

Answer 21

Atomoxetine (Strattera-ER)

Question 22

Clonidine and Guanfacine are both antihypertensive non stimulants used for ADHD, they are both ER, DO NOT crush chew or break tabs, approved 6+ with QD dosing, there is a downward titration over 1 week depending on dose recommended upon discontinuation, due to the rare risk of rebound?

Answer 22

Hypertension that is seen ***