12. CNS Stimulants Flashcards
Stimulants block presynaptic reuptake, interfere with VMAT, increase NT release (NE/DA/5HT). They enhance NT transmission by serving as direct and indirect non catecholamine sympathomimetics
FYI
SE of stimulants include N/V, abdominal pain, headache, decrease appetite, weight loss, reduced growth progression in teens, insomnia, anxiety, jitteriness, irritability, aggression, agitation, psychoses, mania and elevated?
BP/HR
Rare side effects of stimulants include priapism, seizures, sudden cardiac death (rare), stroke and MI, and chemical leukoderma which is basically a?
dry patch (daytrana patch)
Caution using stimulants with axiety/agitation, CV disease, moderate to severe HTN, glaucoma, tourettes, bipolar, psychoses, poorly controlled seizures and with a history of?
drug abuse
Stimulants are controlled substances only allowing 1 month supply, no refills, no samples and onset of activity usually is what in most patients?
24 hours
All of the following are what kind of amphetamine based stimulants? Dextroamphetamine/AMP/Adderall Dextroamphetamine Sulfate/ ProCentra Amphetamine Sulfate / Evekeo Dextramphetamine/ Zenzidi
Immediate release amphetamine based stimulants
What Immediate release amphetamine based stimulants comes in liquid form?
Dextroamphetamine Sulfate/ ProCentra
What Immediate release amphetamine based stimulants comes in tablet form? (2)
Dextroamphetamine/AMP/Adderall
Dextramphetamine/ Zenzidi
What Immediate release amphetamine based stimulants comes in capsule form? (1)
Amphetamine Sulfate / Evekeo
All of the following are what kind of amphetamine base stimulants? Dextroamphetamine/ Adderall XR Dextroamphetamine/Dexedrine Amphetamine/ Dyanavel XR*** Lisdexamfetamine/Vyvanse Amphetamine (mixed salts)/ Mydayis
Extended Release Amphetamine-based Stimulants
Which Extended Release Amphetamine-based Stimulants comes in liquid form? (NOTE ALL OTHERS ARE CAPSULE)
Amphetamine/Dyanavel XR**
What is a form of amphetamine, and XR-oral disintegration tablet, with 50% IR and 50% XR, no water is necessary and approved for ages 6+ with QD dosing?
Adzenys
All of the following are what kind of Methylphenidate-based Stimulants?
Dexmethyphenidate/Focalin
methyphenidate/ methylin
methyphenidate/ Ritalin
Immediate release methyphenidate based stimulants
Which Immediated release methyphenidate based stimulants is the only one that is liquid formulation, all the rest are tablet?
Methyphenidate/Methylin Oral Solution
All of the following are what kind of Methylphenidate-based Stimulants?
Methylphenidate/Ritalin SR
Methylphenidate/Desoxyn
Sustained release Methylphenidate based stimulant
both tablet formation
What is an extended release Methylphenidate based stimulant that is the only one given via transdermal patch?
Methylphenidate Transdermal/ Daytrana
What is an extended release Methylphenidate based stimulant that is the only one given via chewable tablet?
Methylphenidate HCL/ QuilliChew
What is an extended release Methylphenidate based stimulant that is the only one given via liquid formulation?
Methylphenidate/ Quillivant XR
Main MOA for non-stimulants is to enhance NT transmission via inhibition of NE pre-synaptic reuptake (atomoxetine) or agonists of CNS a2a adrenergic receptors which include guanfacine and?
Clonidine
Non-stimulants have an onset of activity of 1-4 weeks*, use for patients intolerant to stimulant effects, they are non-scheduled, refills and samples are allowed and up to how many refills?
1 year of refills
What is a nonstimulant medication, lasts for 24 hours, capsule form, same SE, do NOT open capsul (ocular irritant) and is metabolized by CYP2D6, approved for 6+ and has QD dosing?
Atomoxetine (Strattera-ER)
Clonidine and Guanfacine are both antihypertensive non stimulants used for ADHD, they are both ER, DO NOT crush chew or break tabs, approved 6+ with QD dosing, there is a downward titration over 1 week depending on dose recommended upon discontinuation, due to the rare risk of rebound?
Hypertension that is seen ***
