11. The cardiovascular system Flashcards
Mediastinum
location of heart in a medial section of thoracic cavity, between the lungs
Pericardium
-sac enclosing the heart -made of 3 layers: 1 outer fibrous layer and 2 inner serous pericardium membranes
Fibrous pericardium
loosely fitting outer part of the heart sac, a fibrous layer -protects heart and anchors it to surrounding structures (diaphragm and sternum)
Parietal pericardium
lines interior of fibrous pericardium, at top of heart it’s attached to large arteries leaving the heart and then continues down inferiorly over the heart surface
Visceral pericardium (epicardium)
part of the heart wall, lubricating serous fluid is produced by the serous membranes and collects in-between them in the pericardial cavity
Pericardial cavity
cavity between the parietal pericardium and visceral pericardium surrounding the heart, filled with lubricant produced by these membranes. The fluid allows heart to beat easily without friction
Pericarditis
inflammation of the pericardium. Results in decrease in amount of serous fluid causing pericardial membranes to rub, bind, and stick forming painful adhesions that interfere with heart movement
The heart wall layers:
- the outer epicardium - myocardium - endocardium
Myocardium
middle layer of heart wall, consists of thick bundles of cardiac muscle twisted into ringlike arrangements. Layer that contracts. Myocardial cells are linked by intercalated disks which contain desmosomes and gap junctions. Is reinforced internally by network of dense fibrous connective tissue.
Gap junctions
specialized intercellular connection between a multitude of animal cell-types. They directly connect the cytoplasm of two cells, which allows various molecules, ions and electrical impulses to directly pass through a regulated gate between cells.
Endocardium
thin sheet of endothelium that lines the heart chambers
Pulmonary circulation
circulation of blood from veins into the heart to be pumped into lungs and bind with oxygen and return to heart
Systemic circulation
circulation when heart received oxygen rich blood from lungs and pumps it out to the body where the oxygen is used and CO2 is expelled and then returned to heart as oxygen-poor blood
Atrioventricular (AV) valves
between atria and ventricles. prevent backflow of blood when ventricles contract.
The left AV valve
the bicuspid valve = mitral valve. - 2 flaps or cusps of endocardium
The right AV valve
Tricuspid valve - 3 cusps of endocardium
Chordae tendineae
tiny white chords, anchor cusps to walls of ventricles. As the ventricle contracts, the pressure inside forces AV cusps upward, closing the valves, while the chords ensure the cusps do not flip into atria
Semilunar valves
guard bases of two large arteries leaving ventricular chambers: Pulmonary semilunar valve Aortic Semilunar valve Each has 3 cusps - they are forced open when the ventricles are contracting, and close the ventricles relax and the blood start to flow backwards
Incompetent valve
valve deformation, forces heart to pump and repump same blood because it does not close properly
Valvular stenosis
valve cusps become stiff due to repeated bacterial infection of endocardium, heart must contract much more vigorously to create enough pressure to drive blood through narrowed valve. Ultimately heart weakens, and could fail. Treatment: valve would be replaced with synthetic valve or chemically treated valve from a pig heart
Myocardium blood supply
is supplied by arteries when the heart is at rest
Angina pectoris
When heart is beating fast and rest times are slow, the blood supply to myocardium is low. It is a warning, and if ignored, the heart cells could die due to lack of fresh oxygen
Infarct
area of dead cells in heart
Myocardial infarction
area of heart cells die due to low oxygen supply during short heart rest times =heart attack or coronary
Intrinsic conduction system Nodal system
system which acts to regulate the heart activity. Composed of tissue mix of muscle and nerves. System causes heart muscle depolarisation form atria to ventricles
Sinoatrial (SA) node
=pacemaker tiny cell mass that starts each beat
Heart block
when AV atrioventricular node is damaged, the ventricles start beating at their own pace (slower) Treatment: artificial pacemakers
Ischemia
lack of adequate supply of blood to heart muscle, may lead to fibrillation
fibrillation
rapid uncoordinated quivering of the ventricles. Heart is unable to pump any blood and can be major cause of death Treatment: automatic defibrillators
Tachycardia
rapid heart rate (over 100bpm) Prolonged, could lead to fibrillation
Bradycardia
slow heart rate (less than 60bpm)
Systole
contraction of ventricles
Diastole
relaxation of ventricles (contraction of atrium)
Cardiac cycle (5)
cycle of one heartbeat 0.8 second 1. atrial diastole (ventricular filling) 2. Atrial systole 3. Isovolumetric contraction 4. Ventricular systole (ejection phase) 5. Isovolumetric relaxation
Atrial diastole (ventricular filling)
heart fills with blood from atria to ventricles
Isovolumetric contraction
Atrial systole ends and ventricular systole begins. The pressure closes AV valves. The ventricles are closed
Ventricular systole (ejection phase)
pressure in ventricles causes the semilunar valves to open and blood to be ejected into arteries. Atria are starting to fill with blood