11 Pruritus Flashcards
What is an important mediator in pruritus?
IL-31
What are the two main mediators of itchiness?
Tryptase (non-histaminergic itch) and histamine (histaminergic itch)
What types of nerve fibers are the most important in transmitting itch sensations?
Non-myelinated slow conducting C fibers
What effect does pain have on pruritus?
Negative effect/blocks pruritus sensation
What are the most important histamine receptors?
H1 and H4
What is the most important protease receptor?
PAR-2
What is the most important opioid peptide receptor in pruritus?
Mu
What receptor does benadrayl block?
H1
Which mediators do Apoquel effect?
IL-31 and JAK-1
Cytopoint is an antibody targeting what?
IL-31
What is the threshold phenomenon?
An animal may have a certain pruritic load without clinical signs, but an increased load may push the animal over the threshold and cause clinical pruritus
T or F: mast cells can repopulate granules but not resynthesize mediators
False (they can resynthesize mediators and repopulate granules)
What immunoglobulin is on the surface of mast cells?
IgE
