11: Male Reproductive Physio Clinical Correlations Flashcards
What does 5a-reductase deficiency cause in fetus?
Ambiguous external genitalia
Two conditions that depend on DHT and what treatment can be used for both
BPH and male pattern baldness -> treatment is 5a-reductase inhibitors
T deficiency at 2-3rd month of gestation
Varying degrees of ambiguity of male genitalia
T deficiency at 3rd trimester
Problems with testicular descent + micropenis
T deficiency at puberty
Poor secondary sexual development, eunuchoid features
Eunuchoidism
persistence of prepubertal characteristics, and often presence of characteristics of opposite sex
T deficiency post-puberty
Decreased libido, ED, decreased facial and body hair, low energy, infertility
Two forms of male hypogonadism
Kallman’s syndrome, Klinefelter syndrome
Kallman’s syndrome mechanism
GnRH neurons fail to migrate into hypothalamus
Presentation of Kallman’s syndrome
Delayed or absent puberty, impaired sense of smell, occurs more often in males
A form of hypogonadotropic hypogonadism
Kallman’s syndrome
Klinefelter syndrome mechanism
Seminiferous tubule dysgenesis -> low androgens and high gonadotropins
Genotype of Klinefelter syndrome
47, XXY
Phenotype of Klinefelter syndrome
Appear male at birth, at puberty have increased gonadotropins but fail to induce testicular growth and spermatogenesis -> infertility
By age 80, how many males have BPH?
80%
