11 - Lymphoma and Leukemia 1

Question 1

where are B cells are T cells found in lymph nodes?

Answer 1

B - cortex

T - paracortex

Question 2

leukemia is based in the ____, lymphoma is based in the ____

Answer 2

marrow

lymph node

Question 3

auer rods are associated with which broad type of leukemia

Answer 3

myeloid

Question 4

2 main myeloid markers (CDs)

Answer 4

CD13, CD33

Question 5

main marker for blasts in hemepath (CD)

Answer 5

CD34

Question 6

t(9;22) is assoc w/

Answer 6

CML, some ALL and AML

Question 7

t(8;21) is assoc w/

Answer 7

AML M2

Question 8

t(15;17) is assoc w/

Answer 8

AML M3 (faggot cell w/ lots of auer rods)

Question 9

t(12;21) is assoc w/

Answer 9

ALL

Question 10

inv(16) is assoc w/

Answer 10

AML M4 w/ eosinophilia

Question 11

AML M5 is a neoplasia of what cell type

Answer 11

monocyte

Question 12

AML M7 is a neoplasia of what cell type

Answer 12

megakaryoblast, assoc w/ reticulin fibrosis

Question 13

Non-hodgkin lymphoma compared to Hodgkin lymphoma

Answer 13

nonhodgkin is:
more common
usually have monomorphic growth pattern
neoplastic cell is predominant cell (as opposed to reactive cells in hodgkin’s)
spread is not orderly or continguous like it is in hodgkin lymphoma

Question 14

follicular lymphoma

Answer 14

nonhodgkins
peripheral B cell lymphoma
looks like germinal center B cells - nodular follicular architecture
small cleaved lymphocytes
way too many follicles is low power appearance

Question 15

hodgkin lymphoma - malignant cell

Answer 15

Reed sternberg cell - post germinal center B cells that have forgotten how to be B cells

Question 16

hodgkin lymphoma morphology

Answer 16

few RS cells in background of lymphos, histiocytes, eosinophils, plasma cells, fibrosis

Question 17

what do plasma cell neoplasms tend to look like?

Answer 17

sheets of plasma cells - like to stick together