1.1 intro to cells / cell theory Flashcards

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1
Q

cell theory?

A

living organisms composed of cells; cells as basic units of life; cells can only exist from pre-existing cells [implication?]; 1 or more cells

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2
Q

examples to question cell theory

A
  • striated muscle cell
  • giant algae (acetabularia)
  • aseptate fungal hyphae
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3
Q

why does skeletal muscle not fit the cell theory?

A

challenges idea that cells are small and only contain 1 nuclei

  1. made up of muscle fibres which are enclosed in a membrane (fits)
  2. but they are much larger than most cells - 300mm+ (doesn’t fit)
  3. and they contain hundreds of nuclei [multinucleated] (doesn’t fit)
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4
Q

why does giant algae (acetabularia) not fit cell theory?

A

challenges idea that cells are small

  • can grow up to 100mm in diameter
  • only 1 nucleus
  • complex structures like rhizoids (root-like structures, stalk and cap on top)
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5
Q

why does aseptate fungal hyphae not fit cell theory?

A

challenges idea that individual cells form basic units of life

  • hyphae: long filaments of growth of fungal organisms w numerous branches
  • hyphae can be septate (separated into sections) or aseptate (not in sections)
  • aseptate hyphae: long, uninterrupted structures with numerous nuclei, and do not appear in the form of being made up of many conventional cells
  • continuous cytoplasm
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6
Q

functions of life in cell

A
MERIGRAN
Movement
Excretion
Respiration
Irritability (response)
Growth
Reproduction
Adaptability (regulation due to external changes)
Nutrition (obtaining)
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7
Q

functions of life in paramecium

A

Paramecium:
• Movement – wave action of cilia on cell membrane allows paramecium to move around
• Excretion – cell membrane regulates the movement of molecules in and out of the cell, including the expulsion of metabolic wastes
• Respiration – mitochondria present within paramecium to facilitate cellular respiration
• Irritability (response) – proteins present on cell membrane help detect when contact is made with food (yeast, bacteria, etc) and cilia sweeps food towards the cell mouth
• Growth – Paramecium assimilates nutrients from food for growth
• Reproduction – via binary fission
• Adaptability – Contractile vacuoles can take in and expel water to maintain osmotic potential within the cell
• Nutrition – ingestion of food at cell mouth via phagocytosis and the formation of food vacuoles

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8
Q

functions of life in chlamydomonas

A

Chlamydomonas:
• Movement – presence of flagella allows for movement towards light
• Excretion – cell membrane regulates the movement of molecules in and out of the cell, including the expulsion of metabolic wastes
• Respiration – mitochondria present within cell to facilitate cellular respiration
• Irritability (response) – Contains an eyespot, an organelle reponsible for light detection
• Growth – Chlamydomonas assimilates nutrients from photosynthesis and environment for growth
• Reproduction – via mitosis
• Adaptability – Contractile vacuoles can take in and expel water to
maintain osmotic potential within the cell
• Nutrition – carries out photosynthesis via chloroplasts

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9
Q

2 constraints to cell size

A

• Large enough to store genetic material, resources (nutrients) and
cellular structures that allows for efficient adaptation to life on earth
• Small enough to maintain a high surface area to volume ratio for rapid exchanges of molecules with the external cellular environment

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10
Q

adaptations to maintain high surface area to volume ratio

A

• Cell division (increase cell numbers)
• Compartmentalisation due to presence of membrane bound
organelles
• Folding of cell membrane (e.g. microvilli and crista in mitochondria)
• Extensions (root hair cell)

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11
Q

what is emergent property

A

Emergent properties arise when the interaction of individual components produce new functions

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12
Q

example of a multicellular organism with emergent property from interaction of cellular components

A
  • Caenorhabditis elegans is a multicellular organism that is able to carry out life functions due to the presence of specialised cells
  • Almost one third of cells are nerve cells for coordination and response
  • Muscle cells aid in locomotion by contraction to allow the organism to move by wriggling
  • Presence of reproductive cells (both male and female)
  • Distinct move and anus and intestinal cells to aid in digestion
  • Emergent property – the organism is able to carry out complex functions of life, with these properties arising from the combined effort of multiple specialised cells
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13
Q

organisation of multicellular organisms (how cells group)

A

Cells may be grouped together to form tissues
Organs are then formed from the functional grouping of multiple tissues
Organs that interact may form organ systems capable of carrying out specific body functions
Organ systems collectively carry out the life functions of the complete organism

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14
Q

how do specialised cells develop

A

by differentiation [process during development where newly formed cells become more specialised and distinct from one another as they mature]
all cells share exact same genome
cell specialisation: some genes are expressed and not others
signals sent to deactivate certain genes and others are activated
totipotent stem cells do not have any genes deactivated; are able to turn into any other cell

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15
Q

what are stem cells?

A

undifferentiated / unspecialised cells that can replicate and have the ability to differentiate into specialised cell types

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16
Q

what are the types of stem cells?

A

totipotent – any cell type including early embryonic
pluripotent – any cell type found in human body but not early embryonic or extra-embryonic
multipotent – related cell types (e.g. cord blood cells that can differentiate into diff types of blood cells)
unipotent – can develop into 1 specific cell lineage or cell type

17
Q

use of stem cells to treat stargardt’s disease

A
  • form of macular degeneration
  • gradual loss of vision starting from central vision
  • recessive inherited genetic condition, having a mutant form of gene ABCA4 or other more rare mutant genes
  • ABCA4 codes for ATP dependent transporter protein found in cellular membranes, and is responsible for transport of harmful byproducts of processes that use retinol (from vit a) to produce visual pigments
  • recessive form of gene results in poor transport of harmful byproducts, which accumulate in cells and leads to degeneration of macula
  • treatment: inducing embryonic stem cells to differentiate into retinal cells
  • differentiated cells injected into retina; attach and become fully functional
  • vision restored in time; treatment in clinical trials stage
18
Q

use of stem cells to treat leukemia

A
  • leukemia: blood cancer of white blood cells
  • elevated levels of white blood cells which disrupt proper functioning of body
  • treatment involves use of hematopoietic stem cells (hsc)
  • cancerous bone marrow removed via combo of excision (surgery), radiotherapy and chemotherapy
  • hsc harvested and purified from donor bone marrow or cord blood
  • hsc transplanted within diseased bone marrow region, where cells differentiate and repopulate bone marrow by turning into necessary blood cells
19
Q

compare embryonic stem cells, cord blood cells and adult stem cells

A

ease of extraction from source
• Adult stem cells are hard to find and isolate

Ethical considerations of extraction
• Recognition of an embryo as a human with rights as extraction will result in the death of the embryo (or rather prevention of maturation into a baby)

Potential range of use
• Embryonic stem cells have the greatest potential for use due to its pluripotency, while cord blood cells and adult stem cells are multipotent at best

20
Q

discuss for and against use of embryonic stem cells

A

FOR
• Can cure very serious ailments and diseases that cannot
be cured by other means
• Embryonic stem cells used are donated by parents for scientific use, or would have been lost anyway (abortion or left-overs from IVF therapy)
• Cells taken from embryos do not have nerves and hence cannot feel pain or think for itself

AGAINST
• Involves destruction of human life (at which stage is an
embryo considered a human being?)
• Embryonic stem cells have a greatly increased chance to continue division and turn into cancerous cells
• Potential of wastage where excess embryos are destroyed
• Religious and moral arguments involving man playing as God
• With greater research, alternate means for therapy can be discovered to treat diseases considered to be incurable without the use of stem cells