11: Benign and Malignant Conditions of Vulva/Vagina Flashcards
Androgen insensitivity
Genetic deficiency in androgen receptors of 46XY individual; male gonads with external female phenotype
Most common type of genital cyst
Epidermal inclusion cyst (obstruction of hair follicle)
Vulvar vestibulitis
Rare, infection of vestibular glands; lesions are 1-4mm red dots and EXTREMELY tender
Most common benign solid tumor of vulva
Fibroma - slow growing, but can become large
Atrophic vaginitis
Due to loss of estrogen; atrophy of external genitalia; treat with topical or oral estrogen
Squamous cell hyperplasia (lichen simplex chronicus)
Local thickening of epithelium due to prolonged itching/scratching; pruritis, white/reddish thickened leathery surface, hyperkeratosis; tx with steroid ointment
Lichen sclerosis
Intense pruritus, dyspareunia, burning pain; PE shows thin white parchment like appearance; tx: clobetasol
Bartholin’s cyst
Most common vulvovaginal tumor, unilateral swelling; biopsy if 40+ years to r/o Bartholin’s carcinoma
Most common tumor of vulva
Squamous cell carcinoma - post menopausal women, hx vulvar pruritis
Classic VIN associated with?
HPV (16), smoking, immunocompromise
Differentiated VIN associated with?
Lichen sclerosis, NOT HPV/smoking
Paget’s disease of the vulva
Post-menopausal women, itching/tenderness, biopsy reveals Paget cells; excise the lesion to treat
Most common vaginal cancer
Squamous cell carcinoma
Most common cause of vaginitis
BV - bacterial vaginosis
Most common organism present in BV
Gardnerella vaginalis
