10: Puberty, Menstrual Disorders Flashcards

1
Q

Ovarian cycle - follicular phase

A

Onset of menstruation to LH surge

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2
Q

Ovarian cycle - luteal phase

A

LH surge to 1st day menses

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3
Q

At what point in the menstrual cycle does estrogen peak?

A

Just prior to LH surge

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4
Q

At what point in the menstrual cycle does progesterone peak?

A

5-7 days after ovulation

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5
Q

Corpus luteum

A

Formed after ovulation and secretes progesterone

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6
Q

Corpus albicans

A

Avascular scar that replaces corpus luteum in absence of pregnancy

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7
Q

Menstrual phase

A

RBC extravasation, sloughing of functionalis layer and compression of basalis layer

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8
Q

Proliferative phase

A

Endometrial growth, estrogenic stimulation, increase in arteries, increase in mitoses

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9
Q

Secretory phase

A

Following ovulation, progesterone secretion increases, glands are tortuous, mucus and glycogen secreted, endometrial lining at maximum thickness

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10
Q

Median age of menarche

A

12.43 years

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11
Q

Primary amenorrhea

A

No menstruation by 13 y/o without secondary sexual development OR by 15 years with secondary sexual characteristics

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12
Q

When is menses likely associated with anemia?

A

Greater than 80cc blood loss/changing pad q1-2 hours

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13
Q

Stages of normal pubertal development

A

TAG-ME: Thelarche, Adrenarche, Growth, MEnarche

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14
Q

Thelarche

A

Breast development; 1st sign puberty, requires estrogen

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15
Q

Adrenarche

A

Development of pubic/axillary hair; requires androgens

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16
Q

Maximal growth

A

Occurs ~1 year before onset menses

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17
Q

Menarche

A

Onset of menses

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18
Q

Tanner stage 1

A

Breast: Preadolescent, elevation of papilla only
Hair: Preadolescent, absence of pubic hair

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19
Q

Tanner stage 2

A

Breast: Breast bud, small mound with enlarged areola
Hair: Sparse hair along labia, downy/slight pigment

20
Q

Tanner stage 3

A

Breast: Further enlargement of breast/areola without contour separation
Hair: Spreads sparsely over unction of pubes, darker and coarser

21
Q

Tanner stage 4

A

Breast: Projection of areola from papilla to form secondary mound
Hair: Adult-type hair, no spread to medial thigh

22
Q

Tanner stage 5

A

Breast: Mature, projection of papilla only
Hair: Adult-type hair with spread to medial thighs

23
Q

Precocious puberty

A

Development of secondary sexual characteristics prior to an age 2.5 standard deviations earlier than expected age of pubertal onset (8 y/o in girls)

24
Q

Causes of heterosexual precocious puberty

A

Virulizing neoplasms, CAH, exposure to androgens

25
Q

Causes of isosexual precocious puberty

A

Constitutional or organic brain disease; often idopathic

26
Q

Treatment of isosexual precocious puberty

A

GnRH agonist (Leuprolide) to suppress FSH/LH - prevents stunted growth

27
Q

McCune-Albright syndrome

A

Polyostotic fibrous dysplasia; present with bone defects, cafe au lait spots, adrenal hypercortisolism

28
Q

Peutz-Jeghers syndrome

A

Gastrointestional poyposis and mucocutaneous pigmentation

29
Q

Hypergonadotropic hypogonadism

A

FSH is elevated, gonadal dysgenesis; Turner’s

30
Q

Hypogonadotropic hypogonadism

A

FSH and LH are low; many causes

31
Q

Secondary amenorrhea

A

Patient with prior menses has absent menses for 6+ months

32
Q

Treatment of microadenomas and macroadenomas causing prolactinemia

A

Bromocriptine (Dopamine agonist)

33
Q

Progesterone challenge test

A

Given in secondary amenorrhea if normal TSH/PRL
Positive: bleeding - PCOS
Negative: inadequate estrogenization or outflow tract abnormality

34
Q

Estrogen/progesterone challenge test

A

Given after negative PCT
Negative: outflow tract obstruction
Positive: abnormality in HPA or ovaries

35
Q

Leading cause of female anovulatory infertility

A

PCOS

36
Q

Diagnostic criteria for PCOS

A

At least 2 of the following:

  1. Oligomenorrhea/amenorrhea
  2. Biochemical or clinical signs of hyperandrogenism
  3. US revealing multiple small cysts beneath cortex of ovary
37
Q

Treatment of PCOS

A

Weight loss, OC, clomiphene citrate, spironolactone, metformin

38
Q

Polymenorrhea

A

Abnormally frequent menses at intervals of less than 21 days

39
Q

Menorrhagia

A

Excessive and/or prolonged bleeding (>80 mL and 7 days) at normal intervals

40
Q

Metrorrhagia

A

Irregular episodes of uterine bleeding

41
Q

Menometrorrhagia

A

Heavy and irregular uterine bleeding

42
Q

Intermenstrual bleeding

A

Scant bleeding at ovulation for 1-2 days

43
Q

Oligomenorrhea

A

Menstrual cycles occurring >35 days but less than 6 months

44
Q

PALM-COEIN

A

Polyp-Adenomyosis-Leiomyoma-Malignancy

Coagulopathy-Ovulatory dysfunction-Endometrial-Iatrogenic-Not yet classified

45
Q

Treatment of abnormal uterine bleeding

A

Massive: hospitalization and transfusions, hormones
Moderate: combination OCPs, Mirena
Unresponsive to conservative therapy: D&C, polypectomy, myomectomy, endometrial ablation, hysterectomy