10.17.18 Platelet Production and Function Flashcards

1
Q

Platelets are normally made in the bone marrow from progenitor cells known as ___

A

megakaryocytes

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2
Q

DNA replication continues, but neither the nucleus nor the cell undergoes division

A

endomitosis

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3
Q

What does endomitosis produce?

A

Polyploid cell

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4
Q

Synthesis of this is static and not regulated; made in liver

How are plasma concentrations regulated?

A

TPO

Platelet production rates and by the total mass of platelets and MK

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5
Q

What is the job of GPIa-IIa

A

binds collagen

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6
Q

What is another name for GPIa-IIa

A

a2B1

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7
Q

What is the job of GPIIb-IIIa

A

binds fibrinogen

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8
Q

What is another name for GPIIb-IIIa

A

a2bB3

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9
Q

What is the job of GPIb-IX-V

A

binds von Willebrand factor

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10
Q

What is the job of GPVI

A

activates platelets by binding to collagen

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11
Q

Platelets stick to injured vessel wall via GP Ib-IX-V binding to VWF

A

Adhesion

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12
Q

Resting platelets come in contact with agonists that bind to receptors-signaling occurs-platelets change shape, secrete and activate their GP IIb-IIIa integrins

A

Activation

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13
Q

Platelets stick to each other via fibrinogen bridges binding to activated GP IIb-IIIa

A

Aggregation

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14
Q

Platelets release granular contents and potentiate clotting

A

Secretion

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15
Q

Platelet receptors are GP Ia/IIa and GP VI

A

Collagen

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16
Q

Platelet receptors are P2Y12 and P2Y1

17
Q

Platelet receptor is PAR-1

18
Q

Platelet receptor is a GPCR

A

Thromboxane

19
Q

What keeps platelets from sticking to normal endothelium?

A
  1. Nitric Oxide
  2. Exto-ADPase
  3. Prostacyclin
20
Q

How do you diagnose Qualitative Platelet Disorders?

A

Prolonged bleeding time via PFA-100

PT/PTT/TCT should be normal

21
Q

What are congenital reasons for Qualitative Platelet Disorders?

A
  1. Bernard-Soulier

2. Glanzmann’s Thrombesthenia

22
Q

What are acquired reasons for Qualitative Platelet Disorder?

A
  1. Uremia
  2. ASA, NSAIDs
  3. Myeloproliferative disease
23
Q

This is a defect in Ib/IX on platelet surface so there’s no adhesion

A

Bernard-Soulier

24
Q

this is a defect in IIb/IIIa on platelet surface so there’s no aggregation

A

Glanzmann’s thrombaesthenia

25
What are the symptoms of platelet hypofunction like?
Same defects of primary hemostasis 1. Heavy bleeding 2. Mucocutaneous bleeding (oozing and bruising) 3. Petechia 4. Purpura 5. Abnormal platelet aggregation leading to stroke/heart attack