10.1 Development 3 Flashcards

1
Q

Where does the pituitary gland sit?

A

Sella turcica/pituitary foss aof sphenoid bone above the cavernous sinus.

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2
Q

What is the anterior lobe of the pituitary called? Where does it develop from? Tissue?

A

Adenohypophysis
Rathke’s pouch
Ectoderm

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3
Q

What is the posterior lobe of the pituitary called? Where does it develop from? Tissue?

A

Neurohypophysis
Infundibulum
Neuroectoderm.

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4
Q

Describe the development of the poster lobe.

A

The posterior lobe is formed from a down growth from the diencephalon in the midline - the infundibulum.
Infundibulum extends down towards the roof of the developing oral cavity, retaining its connection with the diencephalon.

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5
Q

What does the part of the diencaphlon from which the infundibulum arises become? Connection between infundibulum and diencephalon?

A

Hypothalamus

Pituitary stalk

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6
Q

What is Rathke’s pouch? how does it devleop?

A

An out pushing from the roof of the oral cavity that grows upwards to meed the infundibulum.
Loses its connection with the roof of the mouth and comes to lie anterior to the infundibulum and wrap around the pituitary stalk.
Differentiates into endocrine cells of anterior pituitary.

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7
Q

What functionally links the anterior lobe to the hypothalamus and the posteror lobe?

A

hypophyseal portal system of blood vessels.

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8
Q

When does the tongue appear?

A

4th week

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9
Q

Describe the development of the tongue.

A

Branchial arches curve around the lateral walls of mouth and pharynx.
Left and right arches meet in the midline ventrally.
The tongue and thyroid gland arise where the branchial arches meet.
5 components come together in tongue development.

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10
Q

What are the 5 components that develop into the tongue? What do they develop from?

A

2 lateral lingual swellings of 1st pharyngeal arch.

3 medial swellings:
1st arch - tuberculum impar
2nd/3rd arches:
Cupola
4th arch
Epiglottal swelling
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11
Q

Describe how the lingual swellings develop into the tongue.

A

Lateral lingual swellings overgrow the tuberculum impar.

Cupola from 3rd arch grows over the 2nd arch component.

Extensive degeneration occurs, freeing the tongue from the floor of the oral cavity, except from the lingual frenulum.

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12
Q

Describe the development of the anterior 2/3 of the tongue.

A

Tuberculum impair forms from the floor of the pharynx atht he level of the 2nd arch.
Paired distal tongue buds from the 1st arch form in front of the tuberculum impair and eventually overgrow and absorb it.

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13
Q

Describe the development of the posterior 1/3 of the tongue.

A

Single swelling, cupola forms in the midline from the 2nd arch.
Larger swelling, hypobranchial eminence forms from the third and fourth arches behind the cupola.
Hypobranchial eminience expands and absorbs the cupola forming the posterior 1/3 (3rd arch) and the epiglottis (4th arch)

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14
Q

Give the innervation of the tongue, general and special sensory and motor.

A

Gen
Ant 2/3 = lingual branch of CNV3 (1st arch nerve)
Post 1/3 = lingual branch of CNIX (3rd arch nerve)

Special
Ant 2/3 Chorda tympani of CNVII (2nd arch nerve –> 1st arch via middle ear))
Post 1/3 = Ligual branch of CNIX (3rd arch nerve)

Motor
All muscles = hypoglossal nerve CNXII
Except palatoglossus = CNX

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15
Q

Where does the thyroid gland first appear? When?

A

Floor of pharynx between tuberculum impair and cupola in 4th week.

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16
Q

What is the site of origin? Marked by what in adults?

A

Lies between branchial arches behind the median tongue bud.

Marked by foramen cecum in adults.

17
Q

Describe the descent of the thyroid gland.

A

The thyroid diverticulum elongates and descends along the midline of the neck and its distal end bifurcates and becomes bi-lobed.

18
Q

What attaches to the thyroid gland to the foramen cecum?

A

Thyroglossal duct

19
Q

What is the final position of the thyroid? When is it reached?

A

Anterior neck

7 weeks

20
Q

What levels of the trachea does the thyroid overly?

A

Central isthmus overlies 2nd and 3rd tracheal cartilages.

21
Q

What is a pyramidal lobe?

A

Remnant of distal end of thyroglossal duct, which usually disappears in 50% of people.
Foramen cecum closes off.

22
Q

What are the 2 cell types of thyroid gland? What do they secrete? What are they formed from?

A

Follicular cells
Secrete T3/T4 Formed from thyroid diverticulum of 1st/2nd branchial arches

Parafollicular C cells
Calcitonin secreted
Ultimobranchial body of 4th pharyngeal pouch

23
Q

What does the parathyroid gland develop from?

A

3rd (inferior) and 4th (superior) pharygeal pouches.

24
Q

What is a thyroglossal cyst? Where are they located?

A

Cystic remnants of the thyroglossal ducts.
May be any point along path of thyroid migration.
50% are close to or inferior to body of hyoid.

25
Q

What is a thyroglossal fistula?

A

Cyst connected to outside.

Arises secondarily after rupture of cyst.

26
Q

When does ectopic thyroid tissue occur Where is it commonly found? What can occur?

A

Failure of thyroid to descent normally.
Found in base of tongue, just behind foramen cecum.
Subject to same diseases as thyroid.

27
Q

What if first arch syndrome? Presentation?

A

Sprectrum of deficits in development of eyes, ears, mandible and palate.
Resulr from failure of colonisation of 1st arch with neural crest cells.

Treacher-COllins Syndrom
Inherited autosomal dominant condition - hypoplasia of mandible and facial bones.

28
Q

What is digeorge syndrome?

A

Deletion on C22 causing variety of defects.
Congenital thymic aplasia, absence of parathyroid.

Cardiac abnormlaity - tetralogy of Fallot
Abnormal facies
Thymic aplasia
Cleft palate
Hypocalcaemia/hypoparathyroidism
22
29
Q

What is CHARGE syndrome?

A

CHD7 heterozygous mutation.
CHD7 is essential for production of neural crest cells.

Coloboma (missing part of iris)
Heart defects
Atresia of chonae
Retardation of growth and development 
Gential hypoplasia
Ear Defects