100: Delusional, Obsessive-Compulsive, and Factitious Skin Diseases Flashcards
What are the primary psychiatric skin disorders and their characteristics?
Primary psychiatric skin disorders are conditions where there is an underlying psychiatric component that leads to self-induced physical findings on the skin. These disorders result in destructive manipulation of the skin, hair, or nails, often as an expression of highly dysregulated emotions. Examples include:
- Delusional disorders
- Morgellons disease
- Body dysmorphic disorder
- Trichotillomania
- Excoriation disorder
- Dermatitis artefacta
What are the clinical features of delusions of parasitosis and Morgellons disease?
The clinical features include:
- Sensations of formication, such as crawling, biting, and stinging, believed to be caused by cutaneous infestation by parasites or fibers.
- Attempts to pick at perceived ‘parasites’ or ‘fibers’.
- Collection of specimens claimed to be extracted from the skin, including scabs, skin flakes, and even real insects.
- Evidence of self-mutilation, with excoriations and irregular ulcers typically sparing areas out of reach.
What is the treatment of choice for delusions of parasitosis?
The treatment of choice is pimozide, followed by atypical antipsychotics. Establishing rapport with the patient is crucial, as they often have low levels of insight and may be resistant to psychiatric treatment.
How is the diagnosis of delusions of parasitosis made?
The diagnosis is a diagnosis of exclusion, made only when the patient has an encapsulated delusion of infestation without the presence of any organic cause.
What are primary psychiatric skin disorders characterized by?
They are characterized by an underlying psychiatric component that causes self-induced physical findings on the skin, resulting in destructive manipulation of the skin, hair, or nails.
What are the clinical features of delusions of parasitosis?
Sensations of formication, including crawling, biting, and stinging, and attempts to pick the ‘parasites’ or ‘fibers’.
What is Morgellons disease a variant of?
It is a variant of delusions of parasitosis, characterized by a fixed belief that there are fibers or solid material extruding from the skin.
What is the matchbox sign in delusions of parasitosis?
It refers to the collection of specimens that patients claim to have extracted from their skin, including scabs, skin flakes, and even real insects.
How are delusions of parasitosis diagnosed?
It is considered a diagnosis of exclusion, made only when there is an encapsulated delusion of infestation without the presence of any organic cause.
What are cutaneous sensory disorders?
Conditions in which the patient has abnormal sensations on the skin, such as itching, burning, stinging, biting, and crawling, without any diagnosable cause.
What are secondary psychiatric disorders associated with psychodermatology?
Anxiety, depression, and social phobia.
What is the challenge in treating delusional skin disorders?
Patients often have low to absent levels of insight and are not open to psychiatric treatment or referral, making establishing rapport key.
What are the primary characteristics of delusional skin disorders?
Delusional skin disorders are characterized by: - Monosymptomatic hypochondriacal diseases with a fixed, false belief.
- Delusions of parasitosis: belief of infestation by parasites or fibers without objective proof.
- Morgellons disease: belief that fibers or solid materials are extruding from the skin.
- Secondary skin findings include excoriation and manipulation of the skin, hair, or nails.
What are the clinical features associated with delusions of parasitosis and Morgellons disease?
Clinical features include:
- Sensations of formication: crawling, biting, and stinging.
- Attempts to pick at perceived parasites or fibers.
- Collection of specimens: scabs, skin flakes, hair, and even real insects (matchbox sign).
- Photographic evidence of their supposed infestation.
- History of antiparasitic therapies attempted without success.
- Self-mutilation: evidence of excoriations and irregular ulcers, often in hard-to-reach areas.
What is the diagnostic approach for delusions of parasitosis?
The diagnosis is a diagnosis of exclusion, which involves: 1. Confirming the presence of an encapsulated delusion of infestation without any organic cause. 2. Assessing if the delusional ideation is part of a broader psychosis (e.g., schizophrenia). 3. Biopsy: while non-diagnostic, it can provide objective evidence against infestation and help build therapeutic rapport with the patient.
What treatment options are available for delusions of parasitosis, and what challenges are associated with management?
Treatment options include:
- Pimozide: first-line treatment for delusions of parasitosis.
- Atypical antipsychotics: used as a follow-up treatment.
Challenges in management:
- Patients often have low insight and may resist psychiatric treatment.
- Establishing rapport is crucial for effective management.
What underlying psychopathology is associated with Body dysmorphic disorder?
- Obsession about a physical flaw
- Comorbid depression, anxiety, or OCD
What are the differential diagnoses for Trichotillomania?
- OCD
- Comorbid anxiety, depression, psychosis
What treatments are available for Neurotic excoriations?
- Wound care
- SSRIs
- Antipsychotics
- Psychotherapy (including DBT)
What is a common characteristic of Dermatitis artefacta?
- Self-induced injury using instruments (sharp objects, lighters, cigarettes, corrosive chemicals)
- Deny self-inflicted nature of skin lesions
What underlying psychopathology is associated with Body dysmorphic disorder?
- Obsession about a physical flaw, often with comorbid depression, anxiety, or OCD.
What are some differential diagnoses for Trichotillomania?
- OCD, comorbid anxiety, depression, and psychosis.
What treatments are recommended for Dermatitis artefacta?
- Wound care, SSRIs, and psychotherapy including DBT.
What is a common characteristic of Neurotic excoriations?
- Self-induced scratching, picking, or rubbing of the skin, often with a relatively high level of insight.
What is the differential diagnosis for Delusions of parasitosis?
- Real infestations, scabies, arthropod bites, and various endocrine and nutritional deficiencies.
What treatments are suggested for Body dysmorphic disorder?
- SSRIs and CBT.
What is the underlying psychopathology of Dermatitis artefacta?
- Psychosocial stressors and a history of physical, emotional, or sexual abuse.
What are the treatments for Trichotillomania?
- SSRIs and habit reversal therapy.
What is a key characteristic of Neurotic excoriations?
- Self-induced injury with a relatively high level of insight and associated shame.
What differential diagnoses should be considered for Body Dysmorphic Disorder?
Differential Diagnoses:
- Concern about a real physical defect.
- Anorexia nervosa.
- Bulimia nervosa.
- Primary psychiatric disease (depression, anxiety, psychosis).
What treatments are recommended for Trichotillomania?
Treatments:
- SSRIs (Selective Serotonin Reuptake Inhibitors).
- Cognitive Behavioral Therapy (CBT).
What are the characteristics and potential treatments for Dermatitis artefacta?
Characteristics:
- Self-induced injury using instruments (sharp objects, lighters, cigarettes, corrosive chemicals).
- Deny self-inflicted nature of skin lesions.
Treatments:
- Wound care.
- SSRIs.
- Antipsychotics.
- Psychotherapy (including DBT).
What underlying psychopathology is associated with Neurotic Excoriations?
Underlying Psychopathology:
- Psychosocial stressor.
- Comorbid depression, anxiety, OCD, BPD, or psychosis.
What are the medical conditions that can be associated with formication, pruritus, or paresthesia?
- Endocrine disorders (diabetes mellitus, hyperthyroidism, hypothyroidism)
- Renal disease (uremic pruritus)
- Nutritional deficiencies (B1, B3, folic acid, B12, iron)
- Neurologic disorders (neuropathy, multiple sclerosis)
- Infections (syphilis)
What is the significance of early intervention in patients with delusions of parasitosis?
Early intervention is important as patients with a shorter duration of active delusion have an increased probability of remission.
What are the common adverse effects of Pimozide (Orap) used for treating delusions of parasitosis?
- Extrapyramidal symptoms such as akathisia and pseudoparkinsonian symptoms
- QT prolongation (for older/cardiac history, baseline EKG and medical clearance is recommended)
What are the characteristics of Body Dysmorphic Disorder (BDD)?
- Preoccupation with a nonexistent or minor physical flaw
- Affects 1.8% to 2.4% of the general population
- Higher prevalence in women
- Onset as early as childhood, mean age 16 years old
- Patients experience embarrassment and avoid confiding in providers.
What are the clinical features of Body Dysmorphic Disorder?
- Fixation on a specific aspect of appearance perceived as unattractive or deformed
- Commonly involves the face, skin, or hair
- Excessive time spent thinking about the defect and attempting to conceal it
- Perform repetitive behaviors like mirror checking and skin picking
- Seek reassurance but receive little to no relief from it.
What must be ruled out in the differential diagnosis of formication?
Real infestation with parasites, such as scabies, and organic causes of symptoms of formication.
What medical conditions can be associated with formication, pruritus, or paresthesia?
Endocrine disorders, renal disease, nutritional deficiencies, neurologic disorders, and infections.
What is the importance of early intervention in patients with delusions?
Patients with a shorter duration of active delusion have an increased probability of remission.
What is the most studied pharmacologic agent for the treatment of delusions of parasitosis?
Pimozide (Orap).
What are common adverse effects of Pimozide?
Extrapyramidal symptoms such as akathisia and pseudoparkinsonian symptoms, and QT prolongation.
What is the primary therapy that works for patients with delusions of parasitosis?
Antipsychotic medications.
What characterizes Body Dysmorphic Disorder (BDD)?
Preoccupation with a nonexistent or minor physical flaw, often leading to embarrassment and avoidance of confiding in providers.
What are the clinical features of Body Dysmorphic Disorder?
Fixation on an aspect of appearance perceived as unattractive, excessive time spent on the defect, and performing repetitive behaviors.
What is the prevalence of Body Dysmorphic Disorder in the general population?
Affects 1.8% to 2.4% of the general population.
What are the characteristics of Obsessive-Compulsive Disorders (OCDs)?
Characterized by intrusive thoughts or urges that are experienced as unwanted, necessitating repetitive behaviors or rituals to alleviate anxiety.
What are the key medical conditions that must be ruled out when diagnosing formication?
- Real infestation with parasites, such as scabies
- Organic causes of symptoms of formication
- Endocrine disorders (e.g., diabetes mellitus, hyperthyroidism, hypothyroidism)
- Renal disease (uremic pruritus)
- Nutritional deficiencies (e.g., B1, B3, folic acid, B12, iron)
- Neurologic disorders (e.g., neuropathy, multiple sclerosis)
- Infections (e.g., syphilis)
What is the significance of early intervention in patients with delusions of parasitosis?
Early intervention is crucial as patients with a shorter duration of active delusion have an increased probability of remission. This highlights the importance of timely management and establishing rapport with patients who may be hesitant to seek psychiatric help.