10. System biology

Question 1

System biology def

Answer 1

computational and mathematical modelling of complex biological systems

Question 2

How to use in practice

Answer 2

Omics ->

Data integration+Pathway identification ->

Identification of biomarker, target or gene of interest

Question 3

Mathematical modelling (2 examples)

Answer 3

Quantitative Logic model
-time series -phenotype
-linear repr. -quantitative
-must know - easy to do
conc - no precis results

Question 4

Software/Tools (5steps)

Answer 4

1. Obtaining datasets from database (TCFA,cBioPortal)
2. First analysis of data sets based on gene expression (Multi experiment viewer - clustering)
3. Networks (STRING, IMP)
4. Pathway analysis (PANTHER, KEGG, DAVID)
5. Metacore