10. Pulpal Immunology Flashcards

1
Q

Pulp histo X symp/sign

A

Seltzer/Bender, Mumford

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2
Q

Tubules dia/density incr near pulp

A

Pashley

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3
Q

Odontoblast process 1/2 way thru tubule

A

Holland

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4
Q

Pulp temp 5.5C Irrev, 11C PN

A

Cohen

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5
Q

Stressed pulp

A

Abou-Rass

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6
Q

Barodontalgia

A

Senia/Cunningham

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7
Q

Pain localization

A

Friend (1/3 pts locate, 80% to 3 tth)

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8
Q

RDT 0.5 mm Irrev dmg

A

Reeves/Stanley, Murray

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9
Q

FPD more likely PN than single crown

A

Cheung

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10
Q

Pulp space present histologically 100%

A

Walton

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11
Q

Immune cells in healthy pulp

A

Jontell/Bergenholtz

Health: macrophages, dendritic cells, T lymphocytes

Inflam: B cells, mast cells, Ig

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12
Q

Immunoglobulins only in inflamed pulp

A

Pulver (IgG,A,M,E)

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13
Q

Innate(<48h)

A

cytokines, neuropeptides, complement

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14
Q

Adaptive(>48h)

A

humoral (B cell/Ig) + cellular (cytotoxic T cell)

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15
Q

Phospholipase A2

A

Membrane phospholipid >> Arachidonic A.

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16
Q

COX-1

A

AA >> Thromboxane (platelet aggreg) and protective PG (GI, renal protective)

17
Q

COX-2

A

AA >> PG involved inflamm

18
Q

Lipooxygenase

A

AA >> leukotriene (bronchospasm, inflamm

19
Q

Types of Hypersensitivity

A

Trowbridge

Type 1: Anaphylaxis (IgE)

Type 2: AntiBody (IgG, IgM - cytotoxic via complement)

Type 3: Immune Complex (Ag-Ig)

Type 4: Delayed cell-mediated (no Ig)

20
Q

Neuropeptides

A

Hargreaves (SP, CGRP, NKA, NPY, VIP)

21
Q

Pulpal vasculature

A

Kim (Pulpal Collateral Circulation – X pulpal strangulation theory)