10. Pulpal Immunology Flashcards
Pulp histo X symp/sign
Seltzer/Bender, Mumford
Tubules dia/density incr near pulp
Pashley
Odontoblast process 1/2 way thru tubule
Holland
Pulp temp 5.5C Irrev, 11C PN
Cohen
Stressed pulp
Abou-Rass
Barodontalgia
Senia/Cunningham
Pain localization
Friend (1/3 pts locate, 80% to 3 tth)
RDT 0.5 mm Irrev dmg
Reeves/Stanley, Murray
FPD more likely PN than single crown
Cheung
Pulp space present histologically 100%
Walton
Immune cells in healthy pulp
Jontell/Bergenholtz
Health: macrophages, dendritic cells, T lymphocytes
Inflam: B cells, mast cells, Ig
Immunoglobulins only in inflamed pulp
Pulver (IgG,A,M,E)
Innate(<48h)
cytokines, neuropeptides, complement
Adaptive(>48h)
humoral (B cell/Ig) + cellular (cytotoxic T cell)
Phospholipase A2
Membrane phospholipid >> Arachidonic A.
COX-1
AA >> Thromboxane (platelet aggreg) and protective PG (GI, renal protective)
COX-2
AA >> PG involved inflamm
Lipooxygenase
AA >> leukotriene (bronchospasm, inflamm
Types of Hypersensitivity
Trowbridge
Type 1: Anaphylaxis (IgE)
Type 2: AntiBody (IgG, IgM - cytotoxic via complement)
Type 3: Immune Complex (Ag-Ig)
Type 4: Delayed cell-mediated (no Ig)
Neuropeptides
Hargreaves (SP, CGRP, NKA, NPY, VIP)
Pulpal vasculature
Kim (Pulpal Collateral Circulation – X pulpal strangulation theory)