11. Periapical Immunology

Question 1

PA histo X symp/signs

Answer 1

Block/Langeland

Stern (cellular comp nsd cyst/gran)

Question 2

Granuloma/cyst make up

Answer 2

Stern #1 fibroblasts (50%), #2 macrophages, #3 lymphocytes, Plasma cells, PMNs)

Question 3

Cyst d(x) Rg size

Answer 3

Lalonde (>200mm2/16mm)

Question 4

Cyst d(x) Rg size inaccurate, need histo

Answer 4

Bornstein/von Arx (CBCT)

Priebe

Question 5

Epithelial Proliferation

Answer 5

Seltzer (Inflamm activate epith cell rests Malassez to prolif + line cavity)

Question 6

Cavitational Breakdown

Answer 6

Ten Cate (central cells die, form cavity)

Question 7

Immunologic Theory

Answer 7

Torabinejad (immune complex causes epithelial prolif)

Question 8

Osmotic Expansion of Cyst Lining

Answer 8

Toll

Question 9

Merging Epithelial Strands

Answer 9

Lin/Rosenberg

Question 10

IgG greatest in granuloma

Answer 10

Pulver

Question 11

IgG and IgA greatest in cyst

Answer 11

Pulver

Question 12

Acute lesions/IgG.A.M.E, Chronic lesions/B.T.cells

Answer 12

Torabinejad

Question 13

IgE high in acute lesions

Answer 13

Svetcov

Question 14

Bone resorption due to

Answer 14

Stashenko IL1-B, TNF-B, PG, BK, T-cell mediated

Question 15

% Cyst

Answer 15

Bhaskar/Lalonde/Spatafore42%,

Nair(6/9%), Simon(8.62%)

Question 16

Lesion size does not affect healing

Answer 16

Caliskan

Question 17

Lesion size affects healing

Answer 17

Ng

Question 18

All cysts heal

Answer 18

Lin

Question 19

True cysts don’t heal

Answer 19

Nair

Question 20

Condensing osteitis

Answer 20

Eliasson 2%, necr60%/vital40%, md post

Question 21

Decompression of cyst

Answer 21

Neaverth

Question 22

Zones of Fish

Answer 22

NCIS

necr/contamination/irritation/stimulation

Question 23

Extraradicular infection

Answer 23

Tronstad/Barnett (biofilm)

Sundqvist (proprionibacterium)

Nair (actino)

Question 24

Foreign bodies in AP

Answer 24

Nair (extru, cholesterol)

Simon (oral pulse)

Question 25

Endotoxin LPS detection

Answer 25

Limulus Amoebocute Lysate test

Question 26

LPS in non-vital, symp, PARL(+)

Answer 26

Schilder

Question 27

PARL Differential

Answer 27

MACHO multilocular

Myxoma, AB, Central giant cell granuloma, Hemangioma, OKC (Multiple OKC - Basal cell nevus syndrome)

cyst/gran/abscess/scar

metastatic cancer, nasopalatine duct cyst, cemento-osseous dysplasia (early), traumatic bone cyst, lateral perio cyst, multiple myleoma, Histiocytosis, Pagets, Browns tumor (HPT)

Question 28

PARO Differential

Answer 28

condensing osteitis, idiopathic osteosclerosis, cemento-osseous dysplasia (late), odontoma, osteoma, cementoblastoma, COC, AOT, CEOT