10: lipoprotein

Question 1

which are amphiphili? which are neutral? pick btw cholesteryl ester, phospholipid, traiuglycerol, choles

Answer 1

phopholipid & + choles: amphihilic
triaglycerol & choles ester: neutral

Question 1

describe 3 types of lipid complex in aq solutions
=> how our body transport lipid

Answer 1

can be:
- liposome / vesicle: bilayer, aq core
- micelle: no core
- microemulsion: single layer, hydrophobic core

Question 2

what are lipoproteins?
inside, triglyceride, ___, ____ ester

Answer 2

spherical microemulsions surrounded by a layer of phospholipid & apolipoprotein
inside, triglyceride, choles, choles ester

Question 3

butter comes from….

Answer 3

buttercomes from churning milk -> solid emerges
centre fat escapes & joins other fat
contains H20-emulsifying fat

Question 4

apolipoprotein: general

Answer 4

has 2 broad classes
wrapped around surface of lipoprotein
recognise the structure so lipoprotein can bind to cells

Question 5

apolipoprotein: exchangeable
molecular mass? hydrophilic? acquire lipid?

Answer 5

AI AII AIII, Ci CII CIII, D. E
small molecular mass
water-soluble in lipid free state
can transfer & acquire lipid in circulation

Question 6

lipoprotein class is defined by ____ (___ -> LOW -> __ __)
the __, the smaller: high ratio of ___, less trig
more __ & ___ ester EXCEPT

Answer 6

density (high -> low -> v low)
the denser, the smaller: protein, less trig
choles, choles except HDL

Question 7

apolipoprotein: non-exchangeable

opp

Answer 7

B100 B48 lil (a)
big!
water-insoluble in lipid free state: except hydrophilic lil (a)
can’t transfer & acquire lipid in circulation; lipid supplied as its made

Question 8

exogenous: disease

chylomicron

Answer 8

familial chylomicro / nemia

Question 9

e

endogenous: 2 diseases

trig rich VLDL / too much choles

Answer 9

abeta lipoprotein/eimia: fatty liver -> keeps on making trig-rich VLDL
familial hypercholes/ rolemia: too much choles

Question 10

chylomicron vs VLDL

Answer 10

1st: B48, C, E
VLDL: same bt B100
both mostly carry trig

Question 11

HDL” composition

Answer 11

A C E
mostly protein, bt also phospholipid & trig

Question 12

LDL: composition

Answer 12

just B100

protein, phospholipid, trig

Question 13

v

reverse choles transport: disease

**choles **

Answer 13

tangier disease: genetic, choles buildup on diff body parts

Question 14

clin measure of lipoprotein

Answer 14

draw blood -> clin analyzer -> create prescription

Question 15

for friedewald equations

TC
HDL-C
TGs ???

Answer 15

total choles in body = TC
HDL choles = HDL-C
trig = TG

Question 16

friedewald equation: fasting

Answer 16

LDL-C= TC - HDL-C - TG/5
Assume that TG/5 = VLDL-C

Question 17

friedewald equation: non-fasting

Answer 17

Non-HDL-C = TC - HDL-C

Question 18

non-trad lipid measuremetn:

Answer 18

A & B concentration

Question 19

monosacc is rep fischer projection

Answer 19

chiral C with 4 diff subtitutents
is superimposable= no matter how u rotate, can’t stack em

Question 20

L vs D glucose

Answer 20

D-glucose has -OH on the Right
L-glucose has -OH on the Left

Question 21

most monosacc is D, look at highest numbered chiral C. T or F.

Answer 21

T

Question 22

aldose vs ketose

Answer 22

aldose has aldehyde (double bond O with H) in the end
ketose has ketone (double bond O)

Question 23

eoi

epimer

Answer 23

isomer; just 1 chiral C with different substituents

Question 24

Haworth: a or b

Answer 24

a- C6 and OH on opp side
B- on same side

Question 25

to convert Fischer into Haworth

Answer 25

If D sugar, C6 points up ; L down
alpha or beta
(rotate to the R) groiups on R point downward; lEFT upward